J Gastroenterology: 富含亮氨酸的α-2糖蛋白是监测阿达木单抗治疗炎性肠病疾病活动的潜在生物标志物

2021-05-06 MedSci原创 MedSci原创

炎性肠病(IBD),如克罗恩氏病(CD)和溃疡性结肠炎(UC)的病因仍是未知的,并且这些基本的患病率正在逐渐增加。

      炎性肠病(IBD),如克罗恩氏病(CD)和溃疡性结肠炎(UC)的病因仍是未知的,并且这些基本的患病率正在逐渐增加。随着治疗的进步,我们能够为IBD患者选择几种合适的治疗选择比如抗肿瘤坏死因子(TNF)药物和免疫抑制剂等。治疗目标也已从临床缓解改变为粘膜愈合,从而降低了住院和手术干预的风险。结肠镜检查是目前监测IBD患者粘膜愈合的金标准。然而,频繁的内窥镜检查是不可能的,因为它是费时,具有侵入性。血清C反应蛋白(CRP)被广泛用作血清生物标志物,用于预测炎症性疾病(包括IBD)的临床活动性。然而,活跃的IBD患者的CRP水平并不总是升高。

 

      研究人员为了寻找一种新的生物标志物,对用英夫利昔单抗治疗的类风湿关节炎患者的血清样本进行全面的蛋白质组学分析,确定了富含亮氨酸的α-2糖蛋白(LRG)是类风湿关节炎疾病活动的新型生物标志物。本项研究旨在研究接受阿达木单抗治疗的IBD患者血清LRG水平与疾病活动性和内窥镜活动的关系。

 

 

      研究人员将接受阿达木单抗治疗的中度至重度IBD的患者纳入本研究。在第0、12、24和52周测量血清LRG,C反应蛋白(CRP)和粪便钙卫蛋白(fCal)水平。在溃疡性结肠炎(UC)患者的第0、12、52周进行结肠镜检查,在第0、24和52周对克罗恩病(CD)进行结肠镜检查。使用CD的克罗恩病简单内镜评分(SES-CD)和UC的Mayo内镜评分(MES)评估内镜活动。最后对LRG,CRP和fCal与疾病活动度进行相关性比较。

 

      本项研究共有81位患者入组,研究结果显示阿达木单抗治疗后IBD患者血清LRG水平下降,同时临床和内窥镜检查结果也有所改善(第0周时为27.4±12.6μg/ ml,第12周时为15.5±7.7μg/ ml,第24周时为15.7±9.6μg/ ml,第52周时为14.5±6.8μg/ ml),与每个时间点的内镜下疾病活动度也呈现下降趋势(SES-CD:第 0周的r = 0.391,第 24周的r=0.563,第 52周的r=0.697)。在汇总分析中,研究人员发现与CRP和fCal相比,内窥镜活动与LRG的相关性更好(SES-CD:LRG:r = 0.636,CRP:r = 0.402,fCal:r =0.435;MES:LRG:r=0.568,CRP:0.389,fCal:r=0.426)。

图:不同生物标记物对于疾病活动度预测能力

       本项研究证实在阿达木单抗治疗期间,血清LRG是CD和UC中内镜活动的最好用的生物标志物。

 

 

原始出处:

Shinichiro Shinzaki. Et al. Leucine-rich alpha-2 glycoprotein is a potential biomarker to monitor disease activity in inflammatory bowel disease receiving adalimumab: PLANET study. Journal of Gastroenterology.2021.

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encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sat May 08 13:26:50 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615654, encodeId=a1c31615654f5, content=<a href='/topic/show?id=3eb39e945b2' target=_blank style='color:#2F92EE;'>#阿达木#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97945, encryptionId=3eb39e945b2, topicName=阿达木)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dba19658752, createdName=1179102698_36768932, createdTime=Sat May 08 13:26:50 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
    2021-11-29 许安
  4. [GetPortalCommentsPageByObjectIdResponse(id=1712797, encodeId=51f41e1279765, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Aug 28 13:26:50 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841676, encodeId=d3e218416e678, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, 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encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sat May 08 13:26:50 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615654, encodeId=a1c31615654f5, content=<a href='/topic/show?id=3eb39e945b2' target=_blank style='color:#2F92EE;'>#阿达木#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97945, encryptionId=3eb39e945b2, topicName=阿达木)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dba19658752, createdName=1179102698_36768932, createdTime=Sat May 08 13:26:50 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1712797, encodeId=51f41e1279765, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Aug 28 13:26:50 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841676, encodeId=d3e218416e678, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, 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createdName=chaojitidian, createdTime=Sat May 08 13:26:50 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561028, encodeId=7b6e156102853, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sat May 08 13:26:50 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567037, encodeId=06c7156e037d8, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sat May 08 13:26:50 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615654, encodeId=a1c31615654f5, content=<a href='/topic/show?id=3eb39e945b2' target=_blank style='color:#2F92EE;'>#阿达木#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97945, encryptionId=3eb39e945b2, topicName=阿达木)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dba19658752, createdName=1179102698_36768932, createdTime=Sat May 08 13:26:50 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1712797, encodeId=51f41e1279765, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Aug 28 13:26:50 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841676, encodeId=d3e218416e678, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, 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encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sat May 08 13:26:50 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615654, encodeId=a1c31615654f5, content=<a href='/topic/show?id=3eb39e945b2' target=_blank style='color:#2F92EE;'>#阿达木#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97945, encryptionId=3eb39e945b2, topicName=阿达木)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dba19658752, createdName=1179102698_36768932, createdTime=Sat May 08 13:26:50 CST 2021, time=2021-05-08, status=1, ipAttribution=)]
  7. 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  8. 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  9. 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  10. 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