Gemphire报告了严重高甘油三酯血症治疗药物gemcabene的中期数据

2018-06-30 MedSci MedSci原创

Gemphire Therapeutics表示,严重高甘油三酯血症(SHTG)患者实验性药物gemcabene的IIb期研究达到了主要终点。 Gemphire认为,这一结果也支持了gemcabene治疗非酒精性脂肪肝(NAFLD)和非酒精性脂肪性肝炎(NASH)的决定。

高甘油三酯血症是一种异族性甘油三酯蛋白合成或降解障碍。指血液中的甘油三酯乳糜微粒和前β-脂蛋白中含量最高,它与动脉粥样硬化的形成有很大的的关系。Gemphire Therapeutics表示,严重高甘油三酯血症(SHTG)患者实验性药物gemcabeneIIb期研究达到了主要终点。 Gemphire认为,这一结果也支持了gemcabene治疗非酒精性脂肪肝(NAFLD)和非酒精性脂肪性肝炎(NASH)的决定。

INDIGO-1试验将91SHTG患者(基线血清甘油三酯(TG)水平至少为500 mg / dL)随机分组,以接受300 mg600 mg每日一次的gemcabene或安慰剂(均含或不含背景他汀治疗)。该研究的主要目标是TG从基线到研究结束的中位变化百分比,而次要终点包括炎症和血清脂质生物标志物的评估。结果显示,给予较高剂量gemcabene的患者的中位TGs显著降低了47%,而安慰剂为27%。Gemphire指出,较高剂量的gemcabene降低了中位TG水平超过300毫克剂量。该公司补充说,在研究结束时,与安慰剂组相比,服用gemcabene 600 mg的患者的血清TG水平中位数水平显著降低了333 mg / dL


原始出处:

http://www.firstwordpharma.com/node/1575605#axzz5JsCRXxz0

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