Gut:急性COVID-19综合征患者肠道微生物群的动态变化

2022-01-27 MedSci原创 MedSci原创

这些结果为COVID-19长期并发症患者肠道微生物组的组成改变提供了观察性的证据。进一步的研究应调查调节肠道微生物群是否可以促进患者从急性COVID-19综合征中恢复。

COVID-19后的长期并发症很常见,但病毒清除后持续症状的潜在原因仍未明确。

近日,消化病领域权威杂志Gut上发表了一篇研究文章,该研究旨在探究肠道微生物组组成是否与急性COVID-19综合征(PACS)相关,PACS定义为SARS-CoV-2病毒清除4周后至少出现一种持续症状。

研究人员对106名COVID-19患者和68名非COVID-19对照者进行了前瞻性研究,从住院到出院后6个月进行了随访。研究人员使用鸟枪法宏基因组测序分析了258个样本的粪便微生物组,并将结局与​​6个月时的持续症状进行关联分析。

6个月时,76%的患者出现PACS,最常见的症状是疲劳、记忆力下降和脱发。入院时的肠道菌群组成与PACS的发生有关。没有PACS的患者在6个月时表现出恢复的肠道微生物组谱,且与非COVID-19对照组相当。PACS患者的肠道微生物组的特征是较高的瘤胃球菌、普通拟杆菌的水平,而普拉氏粪杆菌的水平较低。持续性呼吸道症状与机会性肠道病原体相关,神经精神症状和疲劳与医院肠道病原体相关,包括无害梭菌和内氏放线菌(所有p<0.05)。产丁酸盐的细菌,包括假链状双歧杆菌和prausnitzii粪杆菌,在6个月时与PACS的负相关性最大。

由此可见,这些结果为COVID-19长期并发症患者肠道微生物组的组成改变提供了观察性的证据。进一步的研究应调查调节肠道微生物群是否可以促进患者从急性COVID-19综合征中恢复。

原始出处:

Qin Liu.et al.Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome.Gut.2022.https://gut.bmj.com/content/early/2022/01/05/gutjnl-2021-325989

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    2022-02-03 胡国宏
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    2022-01-29 ms5000000518166734

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