Cancer Res:“饿死”癌细胞的新策略研究获取重要进展!

2017-06-04 sunshine2015 来宝网

为了努力使大脑癌细胞挨饿,并对肿瘤发展进行制动,北卡罗莱纳大学治疗综合性癌症中心研究人员阻止了脑肿瘤细胞用于将糖转化为能量的主要途径。他们希望这会使肿瘤细胞饥饿,并减缓其生长。令人吃惊的是,该策略实际上加速了成神经管细胞瘤实验室模型的增长。

为了努力使大脑癌细胞挨饿,并对肿瘤发展进行制动,北卡罗莱纳大学治疗综合性癌症中心研究人员阻止了脑肿瘤细胞用于将糖转化为能量的主要途径。他们希望这会使肿瘤细胞饥饿,并减缓其生长。令人吃惊的是,该策略实际上加速了成神经管细胞瘤实验室模型的增长。

该研究发表在“癌症研究”杂志上。研究结果可能有助于研究人员在糖代谢途径中找到合适的治疗靶点,并提供一些围绕一些癌细胞从糖中获得能量的混杂方式的科学奥秘线索。

UNC医学院神经病学系的副教授Timothy R. Gershon博士说:“我们的目标是继续找出帮助癌细胞发展的罪魁祸首,并试图阻止它。 “我们将继续在癌细胞中分解这种能量生产途径 - 进行分子解剖,试图找到使癌细胞发展的那部分。”

Gershon说,以前的研究表明,癌细胞依赖于一种称为“有氧糖酵解”的过程,其中存在氧气,但是细胞不能用来从糖中获得最大量的能量。 Gershon说,使用有氧糖酵解的细胞需要使用更多的糖来获得相同的能量。

“这是科学家在20世纪20年代首先提出的一个问题,我们仍然在努力回答这个问题。”Gershon说。 “为什么癌细胞会使用有氧糖酵解?”

糖酵解总体产生较少的能量,并产生称为乳酸的副产物。 Gershon及其合作者以前表明,在生长的大脑细胞中复制的正常细胞的生存依赖于有氧糖酵解。

“虽然大多数细胞只能在氧气不可用时使用糖酵解,但即使在富氧条件下,癌细胞也会一直使用糖酵解。” “没有人知道为什么,但是很多人都希望阻止这种形式的糖酵解是一种治疗癌症的方法。”

Gershon实验室的研究人员已经阻止了细胞在糖酵解过程中使用的不同分子机制,以防止它们产生能量。以前,他们发现删除参与糖酵解的基因,己糖激酶2,在临床前模型中减少脑肿瘤生长。然而,Gershon表示,人类的基因很难破坏,因为它与己糖激酶1类似,对于人类的生存至关重要。所以他们搜索了另一个目标。

Gershon说:“我们研究了糖酵解途径中的其他基因,看看它们是否可能是抑制剂的更好靶标,并且更多地了解该途径如何支持癌症生长。

在新的研究中,他们删除了一个编码称为丙酮酸激酶的分子的基因。然而,删除该基因实际上刺激了实验室模型中的癌细胞生长。

“本文表明,糖酵解的一些步骤增加了肿瘤生长,其他步骤降低了肿瘤生长,”Gershon说。 “我们不知道为什么,但这显然是有所作为的。”

研究人员报告说,两项研究一起显示,癌细胞代谢葡萄糖的方式显着影响其增殖行为。最近的研究指出丙酮酸激酶步骤上游的作用是预防癌症生长的关键。

除了指导未来努力寻找可能阻断癌细胞能量生产的治疗靶点外,研究人员可能已经确定了为什么癌细胞使用这种特殊能量生产途径的可能线索。他们通过细胞追踪糖的路径,缩小葡萄糖存在位置的可能性。根据他们的发现,他们推测,成神经管细胞瘤细胞利用葡萄糖来制造蛋白质,其建立更多的细胞,而不是提供能量。

原始出处:

Katherine Tech, Andrey P Tikunov, et al. Pyruvate kinase inhibits proliferation during postnatal cerebellar neurogenesis and suppresses medulloblastoma formation. Cancer Research. Published OnlineFirst May 17, 2017  doi: 10.1158/0008-5472.CAN-16-3304

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    2017-06-14 zmjlilei

    感谢分享一下吧

    0

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    2017-06-13 zmjlilei

    感谢分享一下

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2026378, encodeId=9a7320263e804, content=<a href='/topic/show?id=4c02960e649' target=_blank style='color:#2F92EE;'>#重要进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96076, encryptionId=4c02960e649, topicName=重要进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Tue Jan 30 09:27:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210584, encodeId=197c21058450, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Jun 14 09:33:59 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210121, encodeId=495921012139, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Tue Jun 13 08:02:10 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209936, encodeId=3839209936d8, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Jun 12 21:39:41 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209441, encodeId=8dfc2094416d, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Jun 11 15:03:29 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208865, encodeId=22822088652d, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Jun 10 07:43:10 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208560, encodeId=971f208560b8, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Jun 09 09:05:37 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208097, encodeId=3c8320809eeb, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Jun 08 09:08:51 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207601, encodeId=368920e601a3, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Jun 07 08:20:08 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207340, encodeId=2e4820e3407e, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 06 13:23:04 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-12 zmjlilei

    感谢分享一下吧

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2026378, encodeId=9a7320263e804, content=<a href='/topic/show?id=4c02960e649' target=_blank style='color:#2F92EE;'>#重要进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96076, encryptionId=4c02960e649, topicName=重要进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Tue Jan 30 09:27:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210584, encodeId=197c21058450, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Jun 14 09:33:59 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210121, encodeId=495921012139, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Tue Jun 13 08:02:10 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209936, encodeId=3839209936d8, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Jun 12 21:39:41 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209441, encodeId=8dfc2094416d, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Jun 11 15:03:29 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208865, encodeId=22822088652d, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Jun 10 07:43:10 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208560, encodeId=971f208560b8, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Jun 09 09:05:37 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208097, encodeId=3c8320809eeb, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Jun 08 09:08:51 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207601, encodeId=368920e601a3, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Jun 07 08:20:08 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207340, encodeId=2e4820e3407e, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 06 13:23:04 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-11 zmjlilei

    感谢分享一下

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2026378, encodeId=9a7320263e804, content=<a href='/topic/show?id=4c02960e649' target=_blank style='color:#2F92EE;'>#重要进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96076, encryptionId=4c02960e649, topicName=重要进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Tue Jan 30 09:27:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210584, encodeId=197c21058450, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Jun 14 09:33:59 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210121, encodeId=495921012139, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Tue Jun 13 08:02:10 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209936, encodeId=3839209936d8, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Jun 12 21:39:41 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209441, encodeId=8dfc2094416d, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Jun 11 15:03:29 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208865, encodeId=22822088652d, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Jun 10 07:43:10 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208560, encodeId=971f208560b8, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Jun 09 09:05:37 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208097, encodeId=3c8320809eeb, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Jun 08 09:08:51 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207601, encodeId=368920e601a3, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Jun 07 08:20:08 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207340, encodeId=2e4820e3407e, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 06 13:23:04 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-10 zmjlilei

    感谢分享一下吧

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2026378, encodeId=9a7320263e804, content=<a href='/topic/show?id=4c02960e649' target=_blank style='color:#2F92EE;'>#重要进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96076, encryptionId=4c02960e649, topicName=重要进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Tue Jan 30 09:27:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210584, encodeId=197c21058450, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Jun 14 09:33:59 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210121, encodeId=495921012139, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Tue Jun 13 08:02:10 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209936, encodeId=3839209936d8, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Jun 12 21:39:41 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209441, encodeId=8dfc2094416d, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Jun 11 15:03:29 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208865, encodeId=22822088652d, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Jun 10 07:43:10 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208560, encodeId=971f208560b8, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Jun 09 09:05:37 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208097, encodeId=3c8320809eeb, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Jun 08 09:08:51 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207601, encodeId=368920e601a3, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Jun 07 08:20:08 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207340, encodeId=2e4820e3407e, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 06 13:23:04 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-09 zmjlilei

    感谢分享一下

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2026378, encodeId=9a7320263e804, content=<a href='/topic/show?id=4c02960e649' target=_blank style='color:#2F92EE;'>#重要进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96076, encryptionId=4c02960e649, topicName=重要进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Tue Jan 30 09:27:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210584, encodeId=197c21058450, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Jun 14 09:33:59 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210121, encodeId=495921012139, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Tue Jun 13 08:02:10 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209936, encodeId=3839209936d8, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Jun 12 21:39:41 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209441, encodeId=8dfc2094416d, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Jun 11 15:03:29 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208865, encodeId=22822088652d, content=感谢分享一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Jun 10 07:43:10 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208560, encodeId=971f208560b8, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Jun 09 09:05:37 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208097, encodeId=3c8320809eeb, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Jun 08 09:08:51 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207601, encodeId=368920e601a3, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Jun 07 08:20:08 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207340, encodeId=2e4820e3407e, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 06 13:23:04 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-08 zmjlilei

    感谢分享一下

    0

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    2017-06-07 zmjlilei

    感谢分享一下

    0

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    2017-06-06 虈亣靌

    学习了,谢谢作者分享!

    0

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