Neuroradiology:用磁共振成像灌注预测多发性硬化病变程度和活动性?也许呢!

2017-06-15 shaosai MedSci原创

对于多发性硬化(MS)的病人,MR灌注加权成像应用并不广泛。尚需进一步的纵向研究来确认基线标准化灌注参数是否可以随着时间的推移区分疾病严重程度和疾病活动亚组。

对于多发性硬化(MS)的病人,MR灌注加权成像应用并不广泛。近日,研究人员在神经放射学杂志Neuroradiology发表了他们利用PWI对MS研究的结果。

该研究主要是对比新诊MS的病人基线时各种灌注参数,来验证利用PWI来根据1年随访病变活动性和严重程度进行分组的假说。本研究共纳入了新诊为复发缓解MS的66例患者并在1.5T MRI扫描仪进行扫描,扫描序列包括DSC-PWI。 从中可以得到脑血流量(CBF),脑血容量(CBV)和平均通过时间(MTT)图。标准化(n)灌注参数=病变侧脑白质每一个灌注参数/正常脑白质相应灌注参数。神经科检查主要在基线时和随访一年后进行来建立多发性硬化严重程度评分(MSSS)系统和收集病变活动性证据(EDA) 。

研究结果为,基线时 MSSS> 3.79的患者(p = 0.016)、EDA的患者(p = 0.041)、MSSS> 3.79并且1年后随访具有EDA的患者(p = 0.032)标准化平均通过时间(nMTT)较低。 在各组间,基线标准化脑血流量(nCBF)和标准化脑血容量(nCBV)没有统计学差异。

研究表明,基线时较低的nMTT与新诊MS患者1年后病情加重和存在疾病活动间相关。同时,尚需进一步的纵向研究来确认基线标准化灌注参数是否可以随着时间的推移区分疾病严重程度和疾病活动亚组。

原始出处:

Sowa P, Nygaard GO, jørnerud A, et al.Magnetic resonance imaging perfusion is associated with disease severity and activity in multiple sclerosis. Neuroradiology. 2017. DOI: 10.1007/s00234-017-1849-4
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    2018-05-27 jml2009
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    2017-06-30 shaosai

    好好学习,涨知识

    0

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    2017-06-19 shaosai

    好好学习,涨知识!

    0

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