GUT：肠道细菌长链脂肪酸与抗炎

2020-09-28 MedSci原创 MedSci原创

肠道细菌产生3-羟基十八烯酸是有效的抗炎成分，其生成微生物/宿主相互作用的结果

临床研究数据表明，益生菌对结肠炎症具有调节作用，但益生菌缓解结肠炎的作用机制尚不清楚。近日研究人员通过质谱，鉴定和量化了益生菌中的游离长链脂肪酸(LCFAs)含量，并评估了其对小鼠结肠炎的影响。

研究人员对大肠杆菌Nissle1917产生的所有LCFA进行质谱研究，与其他大肠杆菌菌株相比，Nissle1917产生的3-羟基十八烯酸 (C18-3OH)浓度增加显著。口服C18-3OH可减轻硫酸葡聚糖钠诱导的小鼠结肠炎。研究人员还发现，益生元低聚果糖(FOS)的抗炎特性与结肠C18-3OH浓度的增加有关。C18-3OH的浓度增加与支原体Allobaculum、霍尔德曼氏菌和狄氏副拟杆菌的丰度增加有关。在培养过程中，BholdemanellaBiformis可产生高浓度的C18-3OH。利用tr-fret结合试验和基因表达分析证明C18-3OH是过氧化物酶体增殖物激活受体γ的激动剂。

研究发现，肠道细菌产生3-羟基十八烯酸是有效的抗炎成分，其生成微生物/宿主相互作用的结果。

原始出处：

Julien Pujo et al. Bacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis.Gut. 21 Sep， 2019.

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2021-04-30 MedSciZeng

#Gut#点击进入话题查看更多相关文章或评论时插入话题加入讨论

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2021-02-19 dearluodi

学习了，谢谢

75 0
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2021-01-22 w984455tii

#长链脂肪酸#

44 0
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2020-09-30 listen318

#肠道细菌#

61 0
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2020-09-29 ms1000000672797977

学习了

104 0
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2020-09-28 Jessica

肠道菌群很重要！

103 0

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