J Thromb Haemost:心肌梗死和肥胖对静脉血栓栓塞风险的联合影响

2022-07-14 MedSci原创 MedSci原创

心肌梗死和肥胖对静脉血栓栓塞风险产生附加性效应,其中46%的静脉血栓栓塞事件归因于二者的相互作用。

心肌梗死与静脉血栓栓塞的风险增加相关。肥胖是心肌梗死和静脉血栓栓塞的已知的危险因素。肥胖是否会进一步增加心肌梗死患者静脉血栓栓塞的风险尚未明确。

近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,该研究旨在探讨心肌梗死与肥胖对静脉血栓栓塞风险的联合影响。

该研究的参与者(n=29410)是从特罗姆瑟研究(1994-1995年、2001年和2007-2008年进行的)的三项调查中招募的,并一直随访至2014年。研究人员记录了随访期间所有心肌梗死和静脉血栓栓塞事件。研究人员采用以心肌梗死为时间因变量的Cox回归模型,通过心肌梗死暴露和肥胖状况的组合来估计静脉血栓栓塞的风险比(根据年龄和性别调整)。此外,研究人员通过计算相互作用的相对超额风险和归因比例(AP)来评估联合效应。

在平均19.6年的随访期间,2090名研究参与者发生了心肌梗塞,784名参与者发生了静脉血栓栓塞。在心肌梗死患者中,55名参与者随后发生静脉血栓栓塞,导致静脉血栓栓塞的总发病率(IR)为5.3人/1000人/年(95%CI为4.1-6.9)。在联合暴露组(心肌梗死+/肥胖+)中,IR为11.3人/1000人/年,调整后的HR表明,与对照组(心肌梗死-/肥胖-)相比,静脉血栓栓塞的风险增加了3倍(HR为3.16,95%CI为1.99-4.99),相应AP为0.46(95%CI为0.17-0.74)。

由此可见,心肌梗死和肥胖对静脉血栓栓塞风险产生附加性效应,其中46%的静脉血栓栓塞事件归因于二者的相互作用。

原始出处:
 
Joakim K. Sejrup.et al.Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study.Journal of Thrombosis and Haemostasis.2022.https://onlinelibrary.wiley.com/doi/10.1111/jth.15812

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    2022-08-17 xue8602
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    2022-08-07 fusion
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    2022-09-02 changfy
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    2022-09-08 ms4000001024001379

    学习打卡

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