Stroke:脑动静脉畸形患者语言相关白质损伤与可塑性

2021-12-01 MedSci原创 MedSci原创

当AVM病灶涉及常规语言区域时,会发生语言相关白质的重构,其重组模式因AVM病灶的位置而异。束状损伤主要由髓鞘缺陷所致,其可塑性可能受轴突重塑过程所支配。

尽管脑动静脉畸形(AVM)病灶可能涉及语言区,但在未破裂AVM患者中很少出现语言功能障碍,这为研究语言重组提供了独特的疾病模型。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,该研究的目的是调查位于不同大脑区域的AVM与语言相关的白质的损伤和重组模式和特征之间的关联。

该研究前瞻性地纳入了33名涉及语言区域的AVM患者。根据病变部位将患者分为3组:额叶组(14名患者)、颞叶组(15名患者)和顶叶组(4名患者)。该研究招募了30名年龄和性别匹配的健康对照作为比较组。所有参与者均进行弥散张量成像扫描检查,并应用自动纤维量化方法定量研究3个AVM组与对照组之间分段语言相关白质连接的差异。

根据西方失语症系列检测,所有受试者的语言功能均正常。在额叶组中,左弓状束的各向异性分数(FA)值降低,而左上纵束和钩状束的各向异性分数(FA)值增加;颞部左侧额枕下束和下纵束FA值降低,右前丘脑放射束和钩状束FA值升高;在顶叶组中,左侧弓状束和下纵束的FA值降低,双侧丘脑前部和钩状束和右侧下额枕叶束的FA值升高。在FA值降低的分束中,径向扩散率的增加较为常见,FA值增加的分束通常伴随轴向扩散率值的增加。

由此可见,当AVM病灶涉及常规语言区域时,会发生语言相关白质的重构,其重组模式因AVM病灶的位置而异。束状损伤主要由髓鞘缺陷所致,其可塑性可能受轴突重塑过程所支配。

原始出处:

Xiaofeng Deng.et al.Impairment and Plasticity of Language-Related White Matter in Patients With Brain Arteriovenous Malformations.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.035506

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    2022-01-06 fusion
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1698300, encodeId=1e831698300e1, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Thu Jan 06 03:45:22 CST 2022, time=2022-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765929, encodeId=9d3f1e65929bf, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Sep 07 22:45:22 CST 2022, time=2022-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642149, encodeId=1b0d164214962, content=<a href='/topic/show?id=5070333625b' target=_blank style='color:#2F92EE;'>#动静脉畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33362, encryptionId=5070333625b, topicName=动静脉畸形)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46c022864035, createdName=12498cf9m42(暂无昵称), createdTime=Tue Oct 25 19:45:22 CST 2022, time=2022-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362359, encodeId=77761362359c9, content=<a href='/topic/show?id=9857e03444b' target=_blank style='color:#2F92EE;'>#畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70344, encryptionId=9857e03444b, topicName=畸形)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Fri Dec 03 12:45:22 CST 2021, time=2021-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398240, encodeId=f87e1398240b6, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Dec 03 12:45:22 CST 2021, time=2021-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418224, encodeId=2a041418224f5, content=<a href='/topic/show?id=a4719180605' target=_blank style='color:#2F92EE;'>#语言#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91806, encryptionId=a4719180605, topicName=语言)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c16b3335392, createdName=yangjxjc, createdTime=Fri Dec 03 12:45:22 CST 2021, time=2021-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076107, encodeId=246d10e61079c, content=过300万的肾衰竭患者需要维持透析治, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Thu Dec 02 09:06:15 CST 2021, time=2021-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076031, encodeId=5a2010e6031a2, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86116159339, createdName=ms8000001592270281, createdTime=Wed Dec 01 22:45:18 CST 2021, time=2021-12-01, status=1, ipAttribution=)]
    2021-12-03 wushaoling
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    2021-12-03 yangjxjc
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    2021-12-02 查查佳佳

    过300万的肾衰竭患者需要维持透析治

    0

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晚期前列腺癌最初对激素治疗有响应,但最终会产生耐药性,从而需要更有效的治疗方法。研究人员在这些患者的10%-20%的比例中观察到的耐药性机制之一是谱系可塑性,表现为部分或完全的小细胞或神经内分泌前列腺