Oncogene:Hsa_circ_0001361可通过miR-491-5p/MMP9途径促进膀胱癌的浸润和转移

2019-11-27 AlexYang MedSci原创

环状RNAs(circRNAs)在各种恶性肿瘤的发展和恶化过程中起着重要的作用。之前的高通量测序研究表明了在膀胱癌中有几百个circRNAs表达异常,并且有研究人员确定了下调的circRNAs circHIPK3、circRNA BCRC-3和circNR3C1在BC的恶化过程中具有抑制作用。最近,有研究人员聚焦于表达上调的circRNAs,并利用RNA-Seq和qRT-PCR鉴定了一个新的环状R

环状RNAs(circRNAs)在各种恶性肿瘤的发展和恶化过程中起着重要的作用。之前的高通量测序研究表明了在膀胱癌中有几百个circRNAs表达异常,并且有研究人员确定了下调的circRNAs circHIPK3、circRNA BCRC-3和circNR3C1在BC的恶化过程中具有抑制作用。

最近,有研究人员聚焦于表达上调的circRNAs,并利用RNA-Seq和qRT-PCR鉴定了一个新的环状RNA,hsa_circ_0001361 (circ0001361)在BC组织和细胞系中高表达,并且该环状RNA与病理阶段和肌肉浸润呈现正相关关系。更多的是,Kaplan-Meier生存分析表明了circ0001361高表达的BC患者总生存较差。功能上来讲,circ0001361能够促进体内和体外BC细胞浸润和转移,但是对细胞周期和增殖没有影响。同时,RNA测序分析表明了MMP9在circ0001361过表达BC细胞中表达上调,并且MMP9能够调控circ0001361诱导的细胞迁移和浸润。更多的是,他们阐释了circ0001361能够直接的与miR-491-5p相互作用来上调MMP9的表达。

最后,研究人员指出,他们的发现表明了circ0001361在BC的浸润和转移中具有致瘤作用,具体是通过靶向miR-491-5p/MMP9途径,并且这也许是BC治疗的新靶标。

原始出处:

Feng Liu, Hui Zhang, Fei Xie et al. Hsa_circ_0001361 promotes bladder cancer invasion and metastasis through miR-491-5p/MMP9 axis. Oncogene. 08 Nov 2019

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    2020-06-28 cy0324
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    2020-03-10 smallant2002
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    2020-03-07 neizongke
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    2019-11-29 zsyan
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    2019-11-27 留走人康

    膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效

    0

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