Lancet psychiatry:COVID-19感染的神经精神并发症发生情况

2020-07-02 MedSci原创 MedSci原创

北京近期新增病例中,有33人发生嗅觉改变,21人发生味觉改变。哈佛大学权威专家:COVID-19会损害人神经系统,引发不同程度的大脑功能损伤。

关于COVID-19潜在神经系统并发症的担忧越来越多,但目前主要是小数据报道。大规模的研究受到地理和专业的限制。临床综合征的综合表征对于合理选择和评估潜在疗法至关重要。本研究目的是在整个英国研究COVID-19神经系统和精神方面的并发症发生情况。

截止2020年4月26日,三个监测平台(ABN、BASP和RCPsycn)共通报了153例与COVID-19相关的临床综合征(包括脑血管事件、精神状态改变、外周神经症状及其他)患者,报告病例呈指数级增长,与英国政府公共卫生机构提供的COVID-19总体数据一致。

这153位患者的中位年龄为71岁(IQR 58-79),其中125位(82%)有完整的临床数据。在这125位患者中,77位(62%)发生脑血管事件:57例缺血性脑卒中、9例脑出血和1例CNS血管炎;39位(31%)出现精神状态改变:9例未明确的脑病和7例脑炎,其他23例精神状态改变的患者符合精神病学诊断的临床病例定义,其中21例(92%)是新增病例。

在23例神经精神疾病的患者中,10例(43%)患有新发精神病,6例(26%)有神经认知(痴呆样)综合征,4例(17%)患有情感障碍。

在37例精神状态改变的患者中,有18位(49%)患者小于60岁,19位(51%)超过60岁,而在74例脑血管事件的患者中,进有13位(18%)患者不足60岁,61位(82%)患者均在60岁以上。

据了解,本研究是第一个针对COVID-19的急性神经和精神并发症的全国性跨专业监测研究。精神状态改变是第二常见的表现,包括脑病或脑炎和原发精神病学诊断,通常发生在相对年轻患者中。本研究为临床医生、研究人员和广大患者提供了迫切需要的有价值的实时数据。

原始出处:

Aravunthan Varatharaj,et al. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. The Lancet Psychiatry. June 25, 2020.

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    2020-09-04 howi
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    2021-03-17 丁鹏鹏
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    2020-07-02 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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