JAMA Neurol:多发性硬化患者需警惕心脑血管疾病风险

2020-05-07 MedSci原创 MedSci原创

多发性硬化患者的心脑血管疾病风险增加,而传统的血管危险因素并不能完全解释这一点

小规模研究发现,多发性硬化症(MS)患者的心血管疾病和死亡率增加,近日研究人员开展基于人群的队列研究,评估多发性硬化患者的大血管事件和死亡风险。
 
研究于1987-2018年间在英国开展,平均随访11.3年。根据年龄、性别和一般情况,共有12251名MS患者与72572名非MS患者参与,研究的主要结果是急性冠状动脉综合征、脑血管疾病、任何大血管疾病(包括外周动脉疾病)和死亡率(全因死亡率和心血管疾病特异性死亡率)。
 
共有12251名MS患者(66.9%女性;平均[SD]年龄,44.9[13.3]岁)与72572名非MS患者(69.8%女性;平均[SD]年龄,44.9[13.3]岁)匹配。与非MS的人相比, MS患者的急性冠脉综合征的危险性增加28%(危险比[HR],1.28),脑血管疾病危险增加59%(HR:1.59),大血管疾病危险增加32%(HR:1.32),全因死亡率增加3.5倍(HR:3.46),心血管疾病死亡率增加1.5倍(HR,1.47)。大血管事件的差异在女性中比男性更明显,女性的死亡率也高于男性。在MS患者中,接受降脂药物(主要是他汀类药物)可降低死亡率。
 
研究认为,多发性硬化患者的心脑血管疾病风险增加,而传统的血管危险因素并不能完全解释这一点。
 
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  1. [GetPortalCommentsPageByObjectIdResponse(id=2001051, encodeId=7d73200105148, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Oct 18 22:30:30 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1890120, encodeId=5152189012003, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Fri May 15 03:30:30 CST 2020, time=2020-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348846, encodeId=956f134884684, content=<a href='/topic/show?id=774951e17e1' target=_blank style='color:#2F92EE;'>#心脑血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51717, encryptionId=774951e17e1, topicName=心脑血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri May 08 10:30:30 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428780, encodeId=1fd41428e80e0, content=<a href='/topic/show?id=c9ae85106df' target=_blank style='color:#2F92EE;'>#脑血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85106, encryptionId=c9ae85106df, topicName=脑血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13c94134529, createdName=lfyang, createdTime=Fri May 08 10:30:30 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473231, encodeId=58d114e3231ee, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Fri May 08 10:30:30 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498723, encodeId=08761498e235d, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Fri May 08 10:30:30 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036083, encodeId=e57e1036083fd, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed May 06 22:30:30 CST 2020, time=2020-05-06, status=1, ipAttribution=)]
    2020-10-18 yinhl1978
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    2020-05-15 jml2009
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    2020-05-06 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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