J Clin Periodontol:荟萃分析结果显示,补充或通过饮食摄入欧米茄-3脂肪酸可有效改善牙周炎病情

2022-04-27 MedSci原创 MedSci原创

牙周病是一种缓慢发展的慢性炎症性疾病,由牙周组织中的致病菌引起,包括牙槽骨、牙周韧带和牙龈。近日,发表于J Clin Periodontol的一项研究评价了欧米茄-3脂肪酸对牙周参数变化的干预效果。

牙周病是一种缓慢发展的慢性炎症性疾病,由牙周组织中的致病菌引起,包括牙槽骨、牙周韧带和牙龈。近日,发表于J Clin Periodontol的一项研究评价了欧米茄-3脂肪酸对牙周参数变化的干预效果。

本荟萃分析包括2010年-2020年间发表的英文研究,检索的数据库包括Cochrane图书馆、EMBASE和PubMed数据库。使用欧米茄-3脂肪酸的摄入量、牙周探诊深度(PPD)、临床附着丧失(CAL)和探诊出血(BOP)来研究欧米茄-3脂肪酸干预的效果。使用随机效应模型分析数据。为了获得模型的稳健性,实施了敏感性分析。根据每个参数的干预期进行了亚组分析。

结果,纳入荟萃分析的所有13项研究都是干预性的随机对照试验。两项研究实施了富含欧米茄-3脂肪酸的饮食,而11项研究使用了补充剂。偏倚的风险很低,没有显示出出版物偏倚。Meta分析显示,欧米茄-3脂肪酸干预总体上有统计学意义的PPD减少(标准化平均差异[SMD]=-0.81,绝对平均差异[MD]=-0.44 mm)、CAL增加(SMD=-0.77,MD=-0.51 mm)和BOP减少(SMD=-0.65,MD=-9.45%)。

综上所述,这项荟萃分析的结果显示,补充欧米茄-3脂肪酸可降低牙周病的临床参数,包括PPD、CAL和BOP。未来有希望通过确认补充ω-3脂肪酸的效果,为牙周疾病患者设定标准,作为一种有效的干预措施,可作为牙周炎管理中的预防和辅助剂使用。

然而,研究的局限性在于,所纳入的研究中部分研究没有提供关于所使用的omega-3脂肪酸或安慰剂细节或明确说明干预措施。未来仍需要大规模的RCTs进一步确认欧米茄-3脂肪酸对牙周炎患者的影响。

 

原始出处:

Hyojin Heo, et al., Supplemental or dietary intake of omega-3 fatty acids for the treatment of periodontitis: A meta-analysis. J Clin Periodontol. 2022 Apr;49(4):362-377. doi: 10.1111/jcpe.13603.  

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    2023-02-13 venlin
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    2023-01-19 feather89
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