Eur Heart J:首次检测到房颤的急性冠脉综合征患者缺血性卒中发生率和死亡率

2021-09-04 MedSci原创 MedSci原创

在ACS患者中,与既往有AF病史的患者相比,首次检测到AF与1年缺血性卒中、死亡和出血发生率之间存在相关性。

近日,血管领域权威杂志Eur Heart J上发表了一篇研究文章,该研究旨在评估急性冠脉综合征(ACS)幸存者且首次检测到房颤(AF)患者1年预后的当代数据。


研究人员使用丹麦全国登记处,确定了2000年至2018年期间首次因ACS入院而幸存下来的所有患者,并将他们分为(i)在ACS之前或期间没有AF的患者;(ii)有房颤病史者;(iii)在ACS入院期间首次检测到AF的患者。随访1年,研究人员使用多变量调整Cox比例风险分析比较研究组之间缺血性卒中、死亡和出血发生率。

该研究纳入了161266名ACS幸存者:135878(84.2%)名无AF者、18961(11.8%)名有AF病史者,以及6427(4.0%)名在ACS入院时首次检测到AF。

与没有AF的患者相比,调整后的1年结局率如下:对于缺血性卒中[有AF病史的患者风险比(HR)为1.38(95%CI为1.22-1.56),首次检测到AF的患者HR为1.67(95%CI为1.38-2.01)];对于死亡率[有AF病史的患者HR为1.25(95%CI为1.21-1.31),首次检测到AF患者的HR为1.52(95%CI为1.43-1.62)];对于出血[有AF病史的患者HR为1.22(95%CI为1.14-1.30)和首次检测到AF患者HR为1.28(95%CI为1.15-1.43)]。
 
由此可见,在ACS患者中,与既往有AF病史的患者相比,首次检测到AF与1年缺血性卒中、死亡和出血发生率之间存在相关性。

原始出处:

Jeppe Kofoed Petersen.et al.Incidence of ischaemic stroke and mortality in patients with acute coronary syndrome and first-time detected atrial fibrillation: a nationwide study.European Heart Journal.2021.https://doi.org/10.1093/eurheartj/ehab575

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    2021-09-06 zhaojie88
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1806456, encodeId=33df1806456ad, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Mon Sep 13 04:10:18 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893414, encodeId=da571893414d3, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Wed Aug 17 07:10:18 CST 2022, time=2022-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826725, encodeId=b7e21826e2521, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Jul 03 00:10:18 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357779, encodeId=f3c7135e779dc, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Sep 06 07:10:18 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432134, encodeId=88301432134bf, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Sep 06 07:10:18 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563517, encodeId=0b77156351ebd, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Sep 06 07:10:18 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026953, encodeId=25af1026953bd, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Sep 04 19:10:18 CST 2021, time=2021-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031466, encodeId=ecfb103146626, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sat Sep 04 19:10:18 CST 2021, time=2021-09-04, status=1, ipAttribution=)]
    2021-09-06 slcumt
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    2021-09-04 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2021-09-04 心介

    房颤,临床上碰到很多哦

    0

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