JGH:自发性细菌性腹膜炎的早期再入院与死亡风险增加有关

2022-07-26 xuyihan MedSci原创

自发性腹膜炎是肝癌、肝硬化、肝腹水的并发症,主要是因为身体免疫力下降,细菌进入腹腔而出现的疾病。

自发性细菌性腹膜炎(SBP)是肝硬化腹水患者的一种常见而严重的并发症,是由致病菌经肠道、血液或者淋巴系统引起的腹腔感染,是在无腹腔内临近器官直接细菌感染来源(如肠穿孔、肠脓肿)的情况下发生于腹腔的感染。多见于晚期肝硬化和其它一些重症肝炎患者及肾病综合征的患者,是终末期肝病患者的重要死亡原因之一,失代偿期肝硬化患者SBP的发生率为l0%~47%,病死率48%~57%,随着对SBP早期诊断和治疗水平的提高,其病死率有所下降,但病死率仍在20%-40%。

因此,对于SBP要积极预防其发生,早诊断,早治疗,从而降低其发病率和病死率。自发性细菌性腹膜炎 (SBP) 的早期再入院通常与不良预后相关。因此,本项研究比较了美国 (US) SBP再入院指数和 30 天再入院的特征和结果。

研究人员分析了2018年全美国再入院数据库,以确定美国所有成人(≥18岁)30 天 SBP 再入院情况。然后比较了SBP指数和30天再入院的住院特征和结果。同时确定了 30 天再入院的独立预测因素。

研究结果显示2018年,在 SBP的 5797个指数入院中,30% (1,726) 在 30 天内重新入院。再入院时,最常见的入院诊断是酒精性肝硬化伴腹水(11.8%),其次是不明微生物引起的败血症(9.2%)。在这30天的再入院中,仅 8.3%将 SBP确定为入院诊断。与普通入院相比,SBP 30 天再入院的平均年龄较低(56.1 岁 vs 58.6 岁,p<0.001)。此外,SBP 30 天再入院与住院死亡率显着增加相关(10% VS 4.9%,OR:2.15,95% CI:1.66-2.79,p<0.001)。

 

本项研究结果证实SBP的30天再入院率为 30%,与普通入院相比,这些再入院与更高的住院死亡率相关。

 

原始出处:

Dushyant Singh Dahiya. et al. Early Readmissions of Spontaneous Bacterial Peritonitis in the United States: Insights into an Emerging Challenge.Journal of Gastroenterology and Hepatology. 2022.

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    2022-07-26 sodoo
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    2022-07-26 xuyong530

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