CHEST:在肥胖低通气综合征患者中,睡眠呼吸暂停可保护心血管

2016-07-10 崔倩 译 MedSci原创

肥胖低通气综合征(OHS)与心血管发病率(CVM)和死亡率高负担有关。大多数OHS患者伴随有阻塞性睡眠呼吸暂停(OSA),但对于OHS患者CVM和OSA严重程度之间的关联数据很少。该研究的目的是评估在一个大队列的OHS患者中,CVM和OSA严重程度之间的关联。在一个横截面分析中,研究人员研究了基于三分位氧饱和度指数(ODI)的OSA严重程度和302名OHS患者的CVM之间的关联。逻辑回归模型被用来

肥胖低通气综合征(OHS)与心血管发病率(CVM)和死亡率高负担有关。大多数OHS患者伴随有阻塞性睡眠呼吸暂停(OSA),但对于OHS患者CVM和OSA严重程度之间关系的研究数据很少。该研究的目的是评估在一个大队列的OHS患者中,CVM和OSA严重程度之间的关联。

在一个横截面分析中,研究人员研究了基于三分位氧饱和度指数(ODI)的OSA严重程度和302名OHS患者的CVM之间的关联。调整各种重要的混杂因素后,逻辑回归模型被用来量化OSA严重程度和CVM之间的独立相关性。

基于ODI作为连续变量或ODI三分位数,CVM的患病率随着的OSA的严重程度的增加显著下降。OSA严重性和CVM的患病率之间的负相关被视为最高ODI的三分位,尽管调整了多混杂因素后,这种关系也一直持续。慢性心脏衰竭与ODI最高的前三分位有最强的负相关性。在第一和第二ODI三分位数之间没有观察到显著CVM风险变化。与最低三分位ODI患者相比,最高三分位ODI患者更年轻,以男性为主,比较肥胖,更加嗜睡,有更糟糕的夜间和白天的气体交换,较低的高血压患病率,更好的运动耐量和更短的住院时间。

在OHS患者中,最高OSA严重程度表型与CVM的风险降低有关。这一发现可以指导今后的临床试验,评估在OHS患者中减少心血管疾病的发病率和死亡率的干预措施的影响。

原始出处:

Juan F. Masa,Jaime Corral,Auxiliadora Romero,et al.Protective Cardiovascular Effect of Sleep Apnea Severity in Obesity Hypoventilation Syndrome,CHEST,2016.7.10

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    2017-06-08 Smile2680
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    2016-09-18 1e10c84am36(暂无匿称)

    不错哦继续关注

    0

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    2016-07-13 黑心天使

    我想知道的是对于肥胖的人,该不该治疗睡眠呼吸暂停呢?

    0

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CHEST:肥胖低通气综合征患者在术前识别高碳酸血症十分有必要

在OSA患者中,与单纯患有OSA患者相比,较多的医疗合并症被认为是与患有肥胖低通气综合征(OHS)相关的。OHS可能会造成择期非心脏手术(NCS)后的术后并发症的风险较高,通常是未知的手术时间。本研究的目的是回顾性识别OHS患者,并与那些只患有OSA的患者比较了他们的手术后的结果。符合OHS标准的患者被确定在一个大型队列中,这些OSA患者在一家大型三级医疗中心接受了择期NCS。研究人员确定了与OS