Am J Rhinol Allergy:次氯酸与生理盐水鼻腔冲洗在过敏性鼻炎中的应用

2021-07-27 AlexYang MedSci原创

过敏性鼻炎(AR)是全球最常见的慢性疾病之一,主要症状包括鼻塞、流鼻涕、打喷嚏和瘙痒。它的特点是鼻粘膜上的Th2免疫介导的超敏反应状况。在免疫学上,AR与鼻粘膜中嗜酸细胞和肥大细胞的浸润增加以及血清中

过敏性鼻炎(AR)是全球最常见的慢性疾病之一,主要症状包括鼻塞、流鼻涕、打喷嚏和瘙痒。它的特点是鼻粘膜上的Th2免疫介导的超敏反应状况。在免疫学上,AR与鼻粘膜中嗜酸细胞和肥大细胞的浸润增加以及血清中抗原特异性IgE水平的升高有关。AR的发病率正在增加,根据韩国国家健康和营养调查,所有年龄段的韩国人口中大约有18.5%的比例受到影响。

低浓度的次氯酸(HOCl)已证明具有止痒、消炎和抗菌的作用,且没有毒性,尽管其机制尚未完全阐明。近期,有研究人员评估了HOCl鼻腔灌洗与生理盐水鼻腔灌洗相比在减少过敏性鼻炎(AR)症状方面的有效性

该研究是一项多中心、随机、双盲、安慰剂对照研究。最初有139名常年过敏性鼻炎患者入选,但是有25名患者没有成功完成研究。患者随机分配到低浓度HOCl(n=55)组或正常盐水(n=59)治组,进行了为期4周的研究。参与者在每次就诊时(基线、第2周和第4周)填写了鼻结膜炎生活质量问卷(RQLQ),并在每天早上和晚上的鼻腔灌洗前后测定鼻腔症状总分(TNSS)。

他们发现,4周后HOCl组和安慰剂组的RQLQ评分明显下降,但两组之间RQLQ评分的下降幅度相似。此外,两组的TNSS在基线和第4周之间都有改善,且两组之间的TNSS变化没有明显差异。HOCl组没有出现任何与鼻腔灌洗有关的临床副作用。

对照组和HOCI组的RQLQ比较

综上所述,低浓度HOCl鼻腔冲洗治疗后过敏症状明显减少,没有明显的不良反应。然而,与生理盐水鼻腔灌洗相比,HOCl对常年性AR患者的症状也没有更多的改善

原始出处:

Ho Chan Kim, Dong-Kyu Kim , Ji Sun Kim et al. Hypochlorous Acid Versus Saline Nasal Irrigation in Allergic Rhinitis: A Multicenter, Randomized, Double-Blind, Placebo-controlled Study. Am J Rhinol Allergy. Jul 2021

 

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    2021-07-29 膀胱癌
  5. [GetPortalCommentsPageByObjectIdResponse(id=1859653, encodeId=c01618596539c, content=<a href='/topic/show?id=fecf69541dd' target=_blank style='color:#2F92EE;'>#生理盐水#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69541, encryptionId=fecf69541dd, topicName=生理盐水)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Sun Aug 01 10:30:07 CST 2021, time=2021-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739955, encodeId=76701e3995556, content=<a href='/topic/show?id=f49c310e134' target=_blank style='color:#2F92EE;'>#冲洗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31071, encryptionId=f49c310e134, topicName=冲洗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ec334602181, createdName=ms3892185887221420, createdTime=Sun Oct 03 10:30:07 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047436, encodeId=44cf204e43692, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Tue Aug 31 19:30:07 CST 2021, time=2021-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329536, encodeId=8b59132953690, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Thu Jul 29 13:30:07 CST 2021, time=2021-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465894, encodeId=fb891465894ea, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Thu Jul 29 13:30:07 CST 2021, time=2021-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003283, encodeId=dc5710032838c, content=挺好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=34c05516956, createdName=ms4000000555981994, createdTime=Wed Jul 28 11:28:19 CST 2021, time=2021-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003182, encodeId=c829100318211, content=感谢分享,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd7a1734546, createdName=1def62fbm10(暂无匿称), createdTime=Tue Jul 27 23:50:44 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003161, encodeId=be981003161d9, content=过敏性鼻炎到底该怎么治?, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65995533818, createdName=顿大侠, createdTime=Tue Jul 27 22:53:28 CST 2021, time=2021-07-27, status=1, ipAttribution=)]
    2021-07-29 mnda
  6. [GetPortalCommentsPageByObjectIdResponse(id=1859653, encodeId=c01618596539c, content=<a href='/topic/show?id=fecf69541dd' target=_blank style='color:#2F92EE;'>#生理盐水#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69541, encryptionId=fecf69541dd, topicName=生理盐水)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Sun Aug 01 10:30:07 CST 2021, time=2021-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739955, encodeId=76701e3995556, content=<a href='/topic/show?id=f49c310e134' target=_blank style='color:#2F92EE;'>#冲洗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31071, encryptionId=f49c310e134, topicName=冲洗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ec334602181, createdName=ms3892185887221420, createdTime=Sun Oct 03 10:30:07 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047436, encodeId=44cf204e43692, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Tue Aug 31 19:30:07 CST 2021, time=2021-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329536, encodeId=8b59132953690, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Thu Jul 29 13:30:07 CST 2021, time=2021-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465894, encodeId=fb891465894ea, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Thu Jul 29 13:30:07 CST 2021, time=2021-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003283, encodeId=dc5710032838c, content=挺好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=34c05516956, createdName=ms4000000555981994, createdTime=Wed Jul 28 11:28:19 CST 2021, time=2021-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003182, encodeId=c829100318211, content=感谢分享,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd7a1734546, createdName=1def62fbm10(暂无匿称), createdTime=Tue Jul 27 23:50:44 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003161, encodeId=be981003161d9, content=过敏性鼻炎到底该怎么治?, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65995533818, createdName=顿大侠, createdTime=Tue Jul 27 22:53:28 CST 2021, time=2021-07-27, status=1, ipAttribution=)]
    2021-07-28 ms4000000555981994

    挺好

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1859653, encodeId=c01618596539c, content=<a href='/topic/show?id=fecf69541dd' target=_blank style='color:#2F92EE;'>#生理盐水#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69541, encryptionId=fecf69541dd, topicName=生理盐水)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Sun Aug 01 10:30:07 CST 2021, time=2021-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739955, encodeId=76701e3995556, content=<a href='/topic/show?id=f49c310e134' target=_blank style='color:#2F92EE;'>#冲洗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31071, encryptionId=f49c310e134, topicName=冲洗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ec334602181, createdName=ms3892185887221420, createdTime=Sun Oct 03 10:30:07 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047436, encodeId=44cf204e43692, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Tue Aug 31 19:30:07 CST 2021, time=2021-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329536, encodeId=8b59132953690, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Thu Jul 29 13:30:07 CST 2021, time=2021-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465894, encodeId=fb891465894ea, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Thu Jul 29 13:30:07 CST 2021, time=2021-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003283, encodeId=dc5710032838c, content=挺好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=34c05516956, createdName=ms4000000555981994, createdTime=Wed Jul 28 11:28:19 CST 2021, time=2021-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003182, encodeId=c829100318211, content=感谢分享,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd7a1734546, createdName=1def62fbm10(暂无匿称), createdTime=Tue Jul 27 23:50:44 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003161, encodeId=be981003161d9, content=过敏性鼻炎到底该怎么治?, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65995533818, createdName=顿大侠, createdTime=Tue Jul 27 22:53:28 CST 2021, time=2021-07-27, status=1, ipAttribution=)]
    2021-07-27 1def62fbm10(暂无匿称)

    感谢分享,受益匪浅

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1859653, encodeId=c01618596539c, content=<a href='/topic/show?id=fecf69541dd' target=_blank style='color:#2F92EE;'>#生理盐水#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69541, encryptionId=fecf69541dd, topicName=生理盐水)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Sun Aug 01 10:30:07 CST 2021, time=2021-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739955, encodeId=76701e3995556, content=<a href='/topic/show?id=f49c310e134' target=_blank style='color:#2F92EE;'>#冲洗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31071, encryptionId=f49c310e134, topicName=冲洗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ec334602181, createdName=ms3892185887221420, createdTime=Sun Oct 03 10:30:07 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047436, encodeId=44cf204e43692, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Tue Aug 31 19:30:07 CST 2021, time=2021-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329536, encodeId=8b59132953690, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Thu Jul 29 13:30:07 CST 2021, time=2021-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465894, encodeId=fb891465894ea, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Thu Jul 29 13:30:07 CST 2021, time=2021-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003283, encodeId=dc5710032838c, content=挺好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=34c05516956, createdName=ms4000000555981994, createdTime=Wed Jul 28 11:28:19 CST 2021, time=2021-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003182, encodeId=c829100318211, content=感谢分享,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bd7a1734546, createdName=1def62fbm10(暂无匿称), createdTime=Tue Jul 27 23:50:44 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1003161, encodeId=be981003161d9, content=过敏性鼻炎到底该怎么治?, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65995533818, createdName=顿大侠, createdTime=Tue Jul 27 22:53:28 CST 2021, time=2021-07-27, status=1, ipAttribution=)]
    2021-07-27 顿大侠

    过敏性鼻炎到底该怎么治?

    0

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Allergy Asthma Clin Immunol:白三烯受体拮抗剂与选择性H1-抗组胺药治疗过敏性鼻炎:当前证据的元分析

过敏性鼻炎(AR)是一种常见的过敏性疾病,由接触过敏原导致的免疫球蛋白E(IgE)相关的鼻膜炎症引起。根据症状的持久性,AR可分为季节性和常年性。AR患者受鼻腔和眼睛症状的影响,干扰了他们的日常生活和

Asian Pac J Allergy Immunol:富马酸卢帕他定治疗常年过敏性鼻炎的疗效和安全性

卢帕他定治疗AR的疗效已在许多临床研究中得到证实,但对亚洲患者的研究非常少。

Allergy Asthma Clin Immunol:治疗树花粉引起的季节性过敏性鼻炎的成本最小化选择:舌下免疫治疗药片

近期,有研究人员进行了成本最小化分析(CMA),评估了在加拿大(安大略省和魁北克省)引入SQ树舌下免疫疗法(SLIT)药片的经济情况,该片剂以ITULATEK®上市(2020年4月获得加拿大卫

World Allergy Organ J:中国不同小麦品种的致敏性评估和过敏原分析

小麦(Triticum aestivum)是世界上种植最广泛的作物,为全球粮食和营养安全做出了重大贡献。小麦富含淀粉、蛋白质、矿物质、B族维生素和生物活性成分,具有很高的营养价值和高适口性。不幸的是,