Life Sci:Tet2下调与过敏性鼻炎调控T细胞的Foxp3 TSDR超甲基化相关

2019-12-16 AlexYang MedSci原创

Tet蛋白是5-甲基胞嘧啶氧化酶,并且对DNA甲基化和基因表达具有深刻的影响。最近,有研究人员调查了过敏性鼻炎(AR)调控T细胞(Treg)中Tet2的作用以及与Foxp3 DNA甲基化的相关性情况。研究人员利用流式细胞仪对AR患者的外周血淋巴细胞和OVA诱导小鼠的脾淋巴细胞进行了分离。研究人员发现,与对照相比,来源于AR患者的OVA诱导的小鼠的Treg细胞数目减少,Foxp3 mRNA和蛋白表达

Tet蛋白是5-甲基胞嘧啶氧化酶,并且对DNA甲基化和基因表达具有深刻的影响。最近,有研究人员调查了过敏性鼻炎(AR)调控T细胞(Treg)中Tet2的作用以及与Foxp3 DNA甲基化的相关性情况。

研究人员利用流式细胞仪对AR患者的外周血淋巴细胞和OVA诱导小鼠的脾淋巴细胞进行了分离。研究人员发现,与对照相比,来源于AR患者的OVA诱导的小鼠的Treg细胞数目减少,Foxp3 mRNA和蛋白表达减少,并且Tet2表达下调。Foxp3 TSDR的超甲基化和TET2结合到Foxp3 TSDR(不包括启动子)的减少在OVA诱导的小鼠中表现明显。在相关性分析中,研究人员还发现Tet2表达与Foxp3 TSDR甲基化以及Foxp3 TSDR甲基化与Foxp3表达存在显著的负相关关系,而Foxp3的表达与Treg细胞比例之间则存在正相关关系。

最后,研究人员指出,他们的研究阐释了Tet2的下调与Foxp3 TSDR更高的甲基化水平、Foxp3表达的减少和AR中Treg细胞比例相关,表明了Tet2很可能通过Foxp3的甲基化来调控Treg细胞的功能。

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    2020-10-16 clmlylxy
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    2020-01-09 zhs3890
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    2020-03-17 yhy100200
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    2019-12-18 neurowu

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