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Nature:抑制基因p16INK4a让肌肉干细胞返老还童

2014-02-21 natureasia natureasia

卫星细胞肌肉衰老
关注

对成年哺乳动物干细胞的功能来说至关重要的特性之一是，长时间保持静止状态的能力以及需要再生时做出反应的能力。骨骼肌数量及功能的损失是人类晚年衰老的共同特征，与被称为“卫星细胞”的骨骼肌干细胞的再生能力的丧失有关。 Pura Mu？oz-Cánoves及同事发现，衰老中的“卫星细胞”发生从静止状态向衰老前状态的不可逆转变，这与已被发现是衰老的一个标志的肿瘤抑制蛋白p16INK4a的表达水平增加有关。

对成年哺乳动物干细胞的功能来说至关重要的特性之一是，长时间保持静止状态的能力以及需要再生时做出反应的能力。骨骼肌数量及功能的损失是人类晚年衰老的共同特征，与被称为“卫星细胞”的骨骼肌干细胞的再生能力的丧失有关。


Pura Mu·oz-Cánoves及同事发现，衰老中的“卫星细胞”发生从静止状态向衰老前状态的不可逆转变，这与已被发现是衰老的一个标志的肿瘤抑制蛋白p16INK4a的表达水平增加有关。成年期间p16INK4a的抑制被发现能将“卫星细胞”保持在一个可逆的静止状态，使肌肉能够再生；p16INK4a在老年人的“卫星细胞”中失调，肌肉再生潜力丧失。

原始出处:

Sousa-Victor P1, Gutarra S2, García-Prat L2, Rodriguez-Ubreva J3, Ortet L4, Ruiz-Bonilla V4, Jardí M4, Ballestar E3, González S5, Serrano AL4, Perdiguero E4, Muñoz-Cánoves P6.Geriatric muscle stem cells switch reversible quiescence into senescence.Nature. 2014 Feb 20

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  1. [GetPortalCommentsPageByObjectIdResponse(id=354796, encodeId=92f5354e96a7, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Dec 08 09:20:21 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879935, encodeId=1af118e993536, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 17 02:47:00 CST 2014, time=2014-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706058, encodeId=31581e0605837, content=<a href='/topic/show?id=d7d55492301' target=_blank style='color:#2F92EE;'>#抑制基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54923, encryptionId=d7d55492301, topicName=抑制基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=964031147987, createdName=xiay994463, createdTime=Mon Jul 14 03:47:00 CST 2014, time=2014-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9319, encodeId=04ab931993, content=但是一旦这些基因激活，同样会带来其它负面影响。人体是平衡的，破坏平衡可以解决一个问题，但也会带来更多的问题！, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed May 07 20:30:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9312, encodeId=91fd931275, content=haowenzhang, yuanenyouma?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=dezutli, createdTime=Wed May 07 17:02:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361621, encodeId=db171361621fe, content=<a href='/topic/show?id=235c94324e2' target=_blank style='color:#2F92EE;'>#返老还童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94324, encryptionId=235c94324e2, topicName=返老还童)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378510, encodeId=cdbb13e8510e2, content=<a href='/topic/show?id=b79a809861a' target=_blank style='color:#2F92EE;'>#肌肉干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80986, encryptionId=b79a809861a, topicName=肌肉干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=)]
    2018-12-08 kafei

    了解一下谢谢

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=354796, encodeId=92f5354e96a7, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Dec 08 09:20:21 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879935, encodeId=1af118e993536, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 17 02:47:00 CST 2014, time=2014-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706058, encodeId=31581e0605837, content=<a href='/topic/show?id=d7d55492301' target=_blank style='color:#2F92EE;'>#抑制基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54923, encryptionId=d7d55492301, topicName=抑制基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=964031147987, createdName=xiay994463, createdTime=Mon Jul 14 03:47:00 CST 2014, time=2014-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9319, encodeId=04ab931993, content=但是一旦这些基因激活，同样会带来其它负面影响。人体是平衡的，破坏平衡可以解决一个问题，但也会带来更多的问题！, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed May 07 20:30:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9312, encodeId=91fd931275, content=haowenzhang, yuanenyouma?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=dezutli, createdTime=Wed May 07 17:02:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361621, encodeId=db171361621fe, content=<a href='/topic/show?id=235c94324e2' target=_blank style='color:#2F92EE;'>#返老还童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94324, encryptionId=235c94324e2, topicName=返老还童)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378510, encodeId=cdbb13e8510e2, content=<a href='/topic/show?id=b79a809861a' target=_blank style='color:#2F92EE;'>#肌肉干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80986, encryptionId=b79a809861a, topicName=肌肉干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=)]
    2014-11-17 liye789132251

    #Nat#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=354796, encodeId=92f5354e96a7, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Dec 08 09:20:21 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879935, encodeId=1af118e993536, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 17 02:47:00 CST 2014, time=2014-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706058, encodeId=31581e0605837, content=<a href='/topic/show?id=d7d55492301' target=_blank style='color:#2F92EE;'>#抑制基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54923, encryptionId=d7d55492301, topicName=抑制基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=964031147987, createdName=xiay994463, createdTime=Mon Jul 14 03:47:00 CST 2014, time=2014-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9319, encodeId=04ab931993, content=但是一旦这些基因激活，同样会带来其它负面影响。人体是平衡的，破坏平衡可以解决一个问题，但也会带来更多的问题！, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed May 07 20:30:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9312, encodeId=91fd931275, content=haowenzhang, yuanenyouma?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=dezutli, createdTime=Wed May 07 17:02:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361621, encodeId=db171361621fe, content=<a href='/topic/show?id=235c94324e2' target=_blank style='color:#2F92EE;'>#返老还童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94324, encryptionId=235c94324e2, topicName=返老还童)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378510, encodeId=cdbb13e8510e2, content=<a href='/topic/show?id=b79a809861a' target=_blank style='color:#2F92EE;'>#肌肉干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80986, encryptionId=b79a809861a, topicName=肌肉干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=)]
    2014-07-14 xiay994463

    #抑制基因#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=354796, encodeId=92f5354e96a7, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Dec 08 09:20:21 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879935, encodeId=1af118e993536, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 17 02:47:00 CST 2014, time=2014-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706058, encodeId=31581e0605837, content=<a href='/topic/show?id=d7d55492301' target=_blank style='color:#2F92EE;'>#抑制基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54923, encryptionId=d7d55492301, topicName=抑制基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=964031147987, createdName=xiay994463, createdTime=Mon Jul 14 03:47:00 CST 2014, time=2014-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9319, encodeId=04ab931993, content=但是一旦这些基因激活，同样会带来其它负面影响。人体是平衡的，破坏平衡可以解决一个问题，但也会带来更多的问题！, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed May 07 20:30:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9312, encodeId=91fd931275, content=haowenzhang, yuanenyouma?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=dezutli, createdTime=Wed May 07 17:02:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361621, encodeId=db171361621fe, content=<a href='/topic/show?id=235c94324e2' target=_blank style='color:#2F92EE;'>#返老还童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94324, encryptionId=235c94324e2, topicName=返老还童)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378510, encodeId=cdbb13e8510e2, content=<a href='/topic/show?id=b79a809861a' target=_blank style='color:#2F92EE;'>#肌肉干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80986, encryptionId=b79a809861a, topicName=肌肉干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=)]
    2014-05-07 lovetcm

    但是一旦这些基因激活，同样会带来其它负面影响。人体是平衡的，破坏平衡可以解决一个问题，但也会带来更多的问题！

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=354796, encodeId=92f5354e96a7, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Dec 08 09:20:21 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879935, encodeId=1af118e993536, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 17 02:47:00 CST 2014, time=2014-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706058, encodeId=31581e0605837, content=<a href='/topic/show?id=d7d55492301' target=_blank style='color:#2F92EE;'>#抑制基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54923, encryptionId=d7d55492301, topicName=抑制基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=964031147987, createdName=xiay994463, createdTime=Mon Jul 14 03:47:00 CST 2014, time=2014-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9319, encodeId=04ab931993, content=但是一旦这些基因激活，同样会带来其它负面影响。人体是平衡的，破坏平衡可以解决一个问题，但也会带来更多的问题！, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed May 07 20:30:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9312, encodeId=91fd931275, content=haowenzhang, yuanenyouma?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=dezutli, createdTime=Wed May 07 17:02:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361621, encodeId=db171361621fe, content=<a href='/topic/show?id=235c94324e2' target=_blank style='color:#2F92EE;'>#返老还童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94324, encryptionId=235c94324e2, topicName=返老还童)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378510, encodeId=cdbb13e8510e2, content=<a href='/topic/show?id=b79a809861a' target=_blank style='color:#2F92EE;'>#肌肉干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80986, encryptionId=b79a809861a, topicName=肌肉干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=)]
    2014-05-07 dezutli

    haowenzhang, yuanenyouma?

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=354796, encodeId=92f5354e96a7, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Dec 08 09:20:21 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879935, encodeId=1af118e993536, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 17 02:47:00 CST 2014, time=2014-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706058, encodeId=31581e0605837, content=<a href='/topic/show?id=d7d55492301' target=_blank style='color:#2F92EE;'>#抑制基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54923, encryptionId=d7d55492301, topicName=抑制基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=964031147987, createdName=xiay994463, createdTime=Mon Jul 14 03:47:00 CST 2014, time=2014-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9319, encodeId=04ab931993, content=但是一旦这些基因激活，同样会带来其它负面影响。人体是平衡的，破坏平衡可以解决一个问题，但也会带来更多的问题！, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed May 07 20:30:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9312, encodeId=91fd931275, content=haowenzhang, yuanenyouma?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=dezutli, createdTime=Wed May 07 17:02:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361621, encodeId=db171361621fe, content=<a href='/topic/show?id=235c94324e2' target=_blank style='color:#2F92EE;'>#返老还童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94324, encryptionId=235c94324e2, topicName=返老还童)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378510, encodeId=cdbb13e8510e2, content=<a href='/topic/show?id=b79a809861a' target=_blank style='color:#2F92EE;'>#肌肉干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80986, encryptionId=b79a809861a, topicName=肌肉干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=)]
    2014-02-23 zhyy88

    #返老还童#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=354796, encodeId=92f5354e96a7, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Dec 08 09:20:21 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879935, encodeId=1af118e993536, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Nov 17 02:47:00 CST 2014, time=2014-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706058, encodeId=31581e0605837, content=<a href='/topic/show?id=d7d55492301' target=_blank style='color:#2F92EE;'>#抑制基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54923, encryptionId=d7d55492301, topicName=抑制基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=964031147987, createdName=xiay994463, createdTime=Mon Jul 14 03:47:00 CST 2014, time=2014-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9319, encodeId=04ab931993, content=但是一旦这些基因激活，同样会带来其它负面影响。人体是平衡的，破坏平衡可以解决一个问题，但也会带来更多的问题！, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed May 07 20:30:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9312, encodeId=91fd931275, content=haowenzhang, yuanenyouma?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=dezutli, createdTime=Wed May 07 17:02:00 CST 2014, time=2014-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361621, encodeId=db171361621fe, content=<a href='/topic/show?id=235c94324e2' target=_blank style='color:#2F92EE;'>#返老还童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94324, encryptionId=235c94324e2, topicName=返老还童)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378510, encodeId=cdbb13e8510e2, content=<a href='/topic/show?id=b79a809861a' target=_blank style='color:#2F92EE;'>#肌肉干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80986, encryptionId=b79a809861a, topicName=肌肉干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ffd5416, createdName=bettycmoon, createdTime=Sun Feb 23 07:47:00 CST 2014, time=2014-02-23, status=1, ipAttribution=)]
    2014-02-23 bettycmoon

    #肌肉干细胞#

    0