JAHA:急性冠脉综合征患者血浆ω-3脂肪酸与心血管事件风险的关系

2021-04-12 MedSci原创 MedSci原创

在急性冠脉综合征患者中,血浆长链ω3-PUFA与心源性猝死的降低几率成负相关,而与传统的危险因素和血脂无关。

在一级预防中,血浆ω-3多不饱和脂肪酸(ω3-PUFAs)与血管死亡风险呈负相关。然而,其与急性冠状动脉综合征风险之间的关系尚未明确。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,在这项包含203名心血管死亡患者、325名心肌梗死患者、271名室性心率失常患者和161名房颤患者的病例队列研究中,研究人员通过气相色谱法评估了受试者基础血浆ω3-PUFA水平(α-亚麻酸、二十碳五烯酸、十二碳五烯酸和二十二碳六烯酸)。研究人员将1612名无事件受试者作为对照者。

在对包括所有传统危险因素的逆概率加权多变量调整后,长链ω3-PUFA(二十碳五烯酸、二十二碳五烯酸和二十二碳六烯酸)的比例相对较高,心血管死亡的几率降低了18%(每1个SD调整后[adj]的比值比[OR]为0.82;95%CI为0.68-0.98),这主要是由心源性猝死几率降低了27%所驱动(每1个SD的adj OR为0.73;95%CI为0.55-0.97)。最高四分位数的长链ω3-PUFA水平与心血管疾病死亡几率降低51%(adj OR为0.49; 95%CI为0.27-0.86)和心源性猝死的几率降低63%(adj OR为0.37; 95%CI为0.16-0.56)相关。

α-亚麻酸与随后的心血管疾病几率(adj OR为0.92;95%CI为0.74-1.14)和心源性猝死(adj OR为0.91;95%CI为0.67-1.25)之间的相关性有所减弱。任何ω3-PUFAs与心源性猝死、心肌梗塞、房颤或急性冠状动脉综合征后早期室性心动过速无关的心血管死亡几率之间均未发现显著相关性。

由此可见,在急性冠脉综合征患者中,血浆长链ω3-PUFA与心源性猝死的降低几率成负相关,而与传统的危险因素和血脂无关

原始出处:

Thomas A. Zelniker.et al.Plasma Omega‐3 Fatty Acids and the Risk of Cardiovascular Events in Patients After an Acute Coronary Syndrome in MERLIN‐TIMI 36.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.017401

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  5. 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createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Tue Apr 13 11:43:11 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956434, encodeId=5a3b9564348e, content=文章很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1914782745, createdName=1101072031, createdTime=Tue Apr 13 07:48:11 CST 2021, time=2021-04-13, status=1, ipAttribution=)]
    2021-04-14 zhaohui6731
  6. 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  7. 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  8. 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  9. 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createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Tue Apr 13 11:43:11 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956434, encodeId=5a3b9564348e, content=文章很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1914782745, createdName=1101072031, createdTime=Tue Apr 13 07:48:11 CST 2021, time=2021-04-13, status=1, ipAttribution=)]
    2021-04-13 ms5000000518166734

    已读,真是受益匪浅呀!

    0

  10. 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createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Tue Apr 13 11:43:11 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956434, encodeId=5a3b9564348e, content=文章很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1914782745, createdName=1101072031, createdTime=Tue Apr 13 07:48:11 CST 2021, time=2021-04-13, status=1, ipAttribution=)]
    2021-04-13 1101072031

    文章很好

    0

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