针对埃博拉病毒的DNA疫苗在临床前研究中显示出长期疗效

2018-10-14 MedSci MedSci原创

发表在《Journal of Infectious Diseases》上的临床前研究数据表明，一种新型合成DNA疫苗可以完全防止埃博拉病毒的感染。

发表在《Journal of Infectious Diseases》上的临床前研究数据表明，一种新型合成DNA疫苗可以完全防止埃博拉病毒的感染。科学家们采用独特的方法设计了优化的DNA疫苗候选物，他们证明了候选疫苗的有效性和动物模型中免疫反应的持久性。结果显示，在最后一次给药后一年，免疫反应强烈，证明了疫苗的长期免疫原性，这是埃博拉疫苗面临的一个特别具有挑战性的领域。

研究人员优化了一种较短的免疫方案，并简化了疫苗直接进入皮肤的方法。这种新方法可以快速抵御病毒攻击并提供保护性免疫。此外，根据该研究，检测到的抗体水平与目前在临床中评估的其他疫苗报道的抗体水平相等或更高。首席研究员大卫韦纳说：“这样的抗埃博拉病毒DNA疫苗可能提供一种重要的保护工具，我们很高兴看到未来的研究将会揭晓”。

埃博拉病毒是丝状病毒科的其中一种病毒，可导致埃博拉出血热，罹患此病可致人于死，包含数种不同程度的症状（包括恶心、呕吐、腹泻、肤色改变、全身酸痛、体内出血、体外出血、发烧等），感染者症状与同为纤维病毒科的马尔堡病毒极为相似。具有50%至90%的致死率，致死原因主要为中风、心肌梗塞、低血容量性休克或器官衰竭。

原始出处：

http://www.firstwordpharma.com/node/1597067#axzz5Trc0A3L7

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2019-01-17 tcm107hq

#埃博拉病#

53 0
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2018-10-16 kafei

了解一下谢谢

78 0
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2018-10-16 redcrab

#埃博拉病毒#

43 0
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2018-10-16 mnda

#DNA疫苗#

30 0
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2018-10-16 gjsgj

#长期疗效#

41 0
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2018-10-14 内科新手

谢谢梅斯提供这么好的信息，学到很多

47 0
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2018-10-14 1e145228m78(暂无匿称)

学习了，谢谢作者分享!

84 0

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针对埃博拉病毒的DNA疫苗在临床前研究中显示出长期疗效

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