J Hypertens:全血中的ω-3脂肪酸浓度与年轻健康成年人的血压呈负相关!

2018-03-23 xing.T MedSci原创

由此可见,较高的Omega-3指数与血压正常的年轻人和健康人SBP和DBP水平降低之间具有显著相关性。富含n-3 FA的饮食可能是高血压一级预防的策略。

在未经治疗的高血压和老年患者中,ω-3脂肪酸(n-3FA)可能具有降血压(BP)的作用。 n-3 FA对年轻健康成年人血压的影响仍不清楚。 Omega-3指数可真实准确的反映个人的 n-3 FA水平。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员假设Omega-3指数与年轻健康成年人的血压水平呈负相关。

该研究(n=2036)是一项横断面研究,调查队列人群的基线特征,其中包括25-41岁的健康成年人。患有心血管疾病、已知糖尿病或BMI高于35kg/m2的个体被排除在外。研究人员使用气相色谱法测定了全血的Omega-3指数。研究人员采用对潜在混杂因素进行调整后的多变量线性回归模型评估了其与诊室和24小时血压之间相关性。

Omega-3指数的中位数为4.58%(四分位距范围为4.08-5.25)。与Omega-3指数最低四分位数的个体相比,Omega-3指数最高水平的个体SBP和DBP分别降低了4和2mmHg(P<0.01)。研究人员观察到Omega-3指数与24小时和诊室血压呈显著的线性负相关。对数转换的Omega-3指数每增加1个单位BP降低,对应的24小时SBP和DBP分别(作为多变量调整的β系数; 95%可信区间)为-2.67mmHg(-4.83; -0.51; P=0.02)和-2.30mmHg (-3.92; -0.68; P=0.005)。

由此可见,较高的Omega-3指数与血压正常的年轻人和健康人SBP和DBP水平降低之间具有显著相关性。富含n-3 FA的饮食可能是高血压一级预防的策略。

原始出处:

Filipovic, Mark,et al.Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults.Journal of Hypertension. 2018.https://journals.lww.com/jhypertension/Abstract/publishahead/Whole_blood_omega_3_fatty_acid_concentrations_are.97505.aspx

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    2019-02-02 feather89
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    2018-03-25 wxl882001

    学习一下

    0

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objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 23 21:24:22 CST 2018, time=2018-03-23, status=1, ipAttribution=)]
    2018-03-25 hmwwww
  9. 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    2018-03-24 yfjms

    学习

    0

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    2018-03-23 虈亣靌

    学习了很有用不错

    0

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2017年5月,发表在《Am J Clin Nutr》的一项基于亚洲女性的队列研究,得出了孕妇血浆ω-3脂肪酸与产后体重保留负相关的结论。