Lancet:熊去氧胆酸与妊娠期肝内胆汁淤积症患者围产期不良结局

2019-08-05 MedSci MedSci原创

研究发现,熊去氧胆酸治疗不能改善妊娠期肝内胆汁淤积症患者的围产期不良结局

妊娠期肝内胆汁淤积症以孕妇瘙痒和血清胆汁酸浓度升高为特征,与死产、早产和新生儿入院率增加有关。近日研究人员评估熊去氧胆酸与减少妊娠肝内胆汁淤积症患者围产期不良结局的关系。

研究在英格兰和威尔士的33个医院开展,招募了妊娠期肝内胆汁淤积症的妇女,患者年龄在18岁或以上,胎龄在20周到40周零6天之间,有单胎或双胎妊娠。参与者随机接受熊去氧胆酸或安慰剂,500毫克每天两次。研究的主要结果是围产期死亡(宫内胎儿死亡或出生后7天的已知新生儿死亡)、早产(小于37周的妊娠)或新生儿住院至少4小时(从出生到出院)。

605名女性,随机接受熊去氧胆酸(n=305)或安慰剂(n=300)。主要结果分析包括熊去氧胆酸组304名妇女和322名婴儿,安慰剂组300名妇女和318名婴儿。熊去氧胆酸组322例婴儿中74例(23%)和安慰剂组318例婴儿中85例(27%)发生主要复合结局(风险比0.85)。在熊去氧胆酸组中报告了2起严重不良事件,安慰剂组报告了6起严重不良事件,严重不良事件均与治疗无关。

研究发现,熊去氧胆酸治疗不能改善妊娠期肝内胆汁淤积症患者的围产期不良结局。

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    2020-03-17 howi
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