Am J Gastroenterol:依鲁沙多林可有效且安全的治疗罗哌酰胺治疗后效果不佳的肠易激综合征患者的腹泻症状

2021-01-14 MedSci原创 MedSci原创

肠易激综合征伴腹泻(IBS-D)是一种功能性胃肠道疾病,患者往往在缓解症状的基础上采取干预措施,但其有效治疗方案仍然有限。近日,发表于Am J Gastroenterol的一项随机对照研究结果证实依鲁

肠易激综合征伴腹泻(IBS-D)是一种功能性胃肠道疾病,患者往往在缓解症状的基础上采取干预措施,但其有效治疗方案仍然有限。近日,发表于Am J Gastroenterol的一项随机对照研究结果证实依鲁沙多林可有效且安全的治疗IBS-D患者的胃肠道症状。

研究将346名IBS-D成年患者随机分配到安慰剂或依鲁沙多林 100 mg每天两次,持续12周。记录患者每日IBS-D症状,包括最严重的腹痛(WAP)和大便稠度。主要终点是应答者的比例,定义为至少50%的治疗天数符合每日复合应答标准(WAP改善≥40%,布里斯托尔粪便量表评分<5),并在12周内记录≥60天的患者。

 

结果显示,在12周内,与安慰剂相比,艾鲁沙多林组达到主要复合反应者终点(22.7% vs 10.3%,P = 0.002),大便稠度改善(27.9% vs 16.7%,P = 0.01)和WAP改善(43.6% vs 31.0%,P = 0.02)的患者比例显著增加。此外,与安慰剂相比,依鲁沙多林组更多的患者达到了每月间隔评估的综合应答者终点(第1-4周:14.0% vs 6.9%,P = 0.03;第5-8周:26.7% vs 14.9%,P = 0.006;第9-12周:30.8% vs 16.7%,P = 0.002)。两组不良事件得发生率相当(37.4% vs 35.3%);没有治疗相关的严重不良事件、Oddi括约肌痉挛病例或胰腺炎的报告。

12周治疗期间每周复合反应者的比例

 

综上所述,该研究结果表明,依鲁沙多林似乎可以安全有效地治疗罗哌酰胺治疗效果不佳的胆囊完好的患者的IBS-D症状。

 

原始出处:

 

Darren M Brenner, Gregory S Sayuk, et al., Efficacy and Safety of Eluxadoline in Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: RELIEF Phase 4 Study. Am J Gastroenterol. 2019 Sep;114(9):1502-1511. doi: 10.14309/ajg.0000000000000327.

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    2021-08-03 许安
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    2021-01-14 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2065247, encodeId=a62f206524e81, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Jun 28 20:38:45 CST 2021, time=2021-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712669, encodeId=85f11e126692a, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Mar 03 15:38:45 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073219, encodeId=ff9320e32198c, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Aug 03 23:38:45 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431996, encodeId=cb301431996f2, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jan 16 06:38:45 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047263, encodeId=c8fc104e2636f, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Jan 14 18:38:45 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916539, encodeId=602c916539a5, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fc22567591, createdName=12577788m05暂无昵称, createdTime=Thu Jan 14 15:42:13 CST 2021, time=2021-01-14, status=1, ipAttribution=)]
    2021-01-14 12577788m05暂无昵称

    很好

    0

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