J Rheumatol:类风湿性关节炎女性患者的性功能障碍

2018-09-04 xiangting MedSci原创

显然FSD在RA女性患者中非常普遍,影响性功能的所有子域,并且在日常临床实践中极可能被低估。

这项研究旨在评估类风湿性关节炎(RA)对女性性行为的影响,其中包括动机、活动和满意度,并评估性功能疾病相关性机体损伤的相关性。

采用标准化问卷对R A女性患者和健康对照(HC)进行匿名调查,主要是性功能问卷简表(CSFQ-14)的变化。此外,评估了疾病活动性、抑郁和残疾。

向患者分发了319份问卷,向HC分发了306份。返回235份患者问卷(73.7%)和180份HC问卷(58.8%),其中分别完成203份和169份。在RA患者中,47.8%患者的总CSFQ-14评分≤41,表明女性性功能障碍(FSD),而HC为14.2%(p<0.0001)。RA患者的中位CSFQ-14评分[42分,四分位间距(IQR)36-48]低于HC患者(49分,IQR 44-54; p<0.0001),OR值为5.53(95%CI 3.19-9.57;p<0.0001)。调整混杂因素后,考虑到患者的平均年龄(55.2±11.3岁)高于HC(47.4±11.8岁;p<0.0001),RA患者FSD的OR值仍为3.04(95%CI为1.61-5.75;p=0.001)。调整后,健康评估问卷-残疾指数和临床疾病活动性指数均与FSD无关。

显然FSD在RA女性患者中非常普遍,影响性功能的所有子域,并且在日常临床实践中极可能被低估。值得注意的是,FSD与残疾或RA疾病活动性无关。

原始出处:

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    2018-09-06 lmm397
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    2018-09-05 13718711b3m

    学习了,非常不错的临床经验,值得借鉴,涨知识,受益匪浅,感谢分享!

    0

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    2018-09-04 happsf

    学习

    0

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类风湿关节炎(Rheumatoid Arthritis,RA)是一种以炎性滑膜炎为主的慢性自身免疫性疾病,可发病于腰部以外的任何关节。全球有超过2300万人患有此病,多在中年发作,女性患者数量是男性的3倍。间充质干细胞(Mesenchymal Stem Cells,MSCs)作为来源于中胚层的非造血结缔组织的前体,广泛存在于骨髓、脂肪组织等实体器官间质中。MSCs的主要来源有:骨髓、外周血、脐

警惕,关节炎也可能出现眼部病变

眼部受累是诸多系统性风湿病的一个常见的重要临床表现,最常见于类风湿关节炎、脊柱关节病等疾病。眼部受累的原因可能是炎症性的,也可能是血管性、感染性和医源性的。眼部受累可累及眼睛的各个部分,且一些眼部受累具有诊断提示性,如类风湿关节炎患者的巩膜表层炎。但大多数眼部受累缺乏特异性,如干眼症。

PLos One:RA患者MTX治疗期间肝活检中的非酒精性脂肪性肝炎样类型

RA低剂量MTX治疗期间,NAFLD/NASH与肝损伤之间的风险因素和组织学发现相似,这表明两种疾病之间存在紧密关联。

Arthritis Rheumatol:抗瓜氨酸蛋白抗体交叉反应的结构基础

这项研究数据首次揭示了来自人类RA的ACPA如何识别瓜氨酸。