Blood:CLL患者接种新冠BNT162b2 mRNA疫苗后的抗体反应

2021-06-14 Nebula MedSci原创

CLL患者对COVID-19的BNT162b2 mRNA疫苗的抗体介导的反应明显受损,而且受CLL疾病活性和治疗情况的影响

新冠疫苗接种正在如火如荼的进行着,尤其是在广州、台湾疫情爆发的情况下,人们对接种新冠疫苗的越来越积极。那么,癌症患者能够接种新冠疫苗?目前缺乏相应的临床试验数据,新冠疫苗对癌症患者的安全性和有效性也尚不明确

慢性淋巴细胞白血病 (CLL) 患者感染新冠病毒后发生危重症新冠肺炎COVID-19)和死亡的风险高于普通人群。《血液》杂志上最新发表的临床试验“Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia”,评估了COVID-19疫苗对CLL患者的保护作用

Herishanu等人评估了CLL患者对COVID-19 BNT162b2信使RNA(mRNA) 疫苗的体液免疫反应,并与匹配的年龄健康对照受试者的反应进行了比较。患者间隔21天接种完两针疫苗后,采用Elecsys Anti-SARS-CoV-2 S测定法检测抗体效价。

CLL患者和健康对照个体的抗SARS-CoV-2抗体反应

共纳入了167位CLL患者,抗体反应率为39.5%52位CLL患者和52位性别、年龄匹配的健康对照受试者的反应对比显示,CLL患者的抗体反应率显著降低(52% vs 100%;校正优势比 0.010,95%CI 0.001-0.162;p<0.001)。

治疗情况对抗体反应率的影响

在CLL患者中,经治疗后获得临床缓解的CLL患者的抗体反应率最高(79.2%),其次是未治疗过的患者(55.2%),接种疫苗时正在接受抗CLL治疗的患者的抗体反应率最低(16.0%)。在接受Bruton酪氨酸激酶抑制剂或维奈托克±抗CD20抗体治疗的患者中,抗体反应率相当低(16.0%和13.6%)。接种前12个月内暴露于抗CD20抗体的患者均对疫苗无反应。

在多变量分析中,抗体反应的独立预测因子有年龄较小、女性、目前无积极治疗、免疫球蛋白G水平≥550 mg/dL和免疫球蛋白M水平≥40 mg/dL

综上所述,CLL患者对COVID-19的BNT162b2 mRNA疫苗的抗体介导的反应明显受损,而且受CLL疾病活性和治疗情况的影响

原始出处:

Yair Herishanu, et al. Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia. Blood (2021) 137 (23): 3165–3173.

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    2021-06-26 任我行3313

    所以疫苗有针对的人群

    0

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    2021-06-14 小小医者

    #新冠疫苗#细分人群的观察

    0

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    2021-06-14 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1947392, encodeId=7906194e39299, content=<a href='/topic/show?id=88d81556543' target=_blank style='color:#2F92EE;'>#RNA疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15565, encryptionId=88d81556543, topicName=RNA疫苗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce072500140, createdName=12498b3em08(暂无昵称), createdTime=Wed Sep 15 23:59:47 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977145, encodeId=13df9e7145ae, content=所以疫苗有针对的人群, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=oywRKRLSzibJMv3JHUmUVJQ&s=100&t=1557394800, createdBy=81e05325887, createdName=任我行3313, createdTime=Sat Jun 26 22:13:11 CST 2021, time=2021-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973596, encodeId=10ef9e3596f6, content=<a href='/topic/show?id=4dbd580630b' target=_blank style='color:#2F92EE;'>#新冠疫苗#</a>细分人群的观察, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58063, encryptionId=4dbd580630b, topicName=新冠疫苗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Mon Jun 14 23:15:47 CST 2021, time=2021-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029594, encodeId=04fb1029594dd, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Mon Jun 14 19:59:47 CST 2021, time=2021-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973510, encodeId=58dd9e35107a, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Mon Jun 14 18:19:33 CST 2021, time=2021-06-14, status=1, ipAttribution=)]
    2021-06-14 医鸣惊人

    认真学习了

    0

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