Crit Care:创伤后脑梗死对TBI患者预后的影响

2020-02-06 xing.T MedSci原创

由此可见,PTCI是中度或重度TBI患者常见并发症,并且是长期残疾的独立危险因素。在IMPACT核心和扩展的预测模型中添加PTCI可以显著提高其在预测GOS方面的性能。

创伤性脑梗死(TBI)后常见于颅脑外伤(PTCI)患者。目前尚不清楚PTCI如何发生,它对患者长期结局的影响如何,以及是否会为既定的结局预测因素增加预后价值。

近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,该研究是对中度和重度TBI患者进行的前瞻性多中心队列研究,主要目标是评估PTCI是否是使用格拉斯哥成果量表(GOS)评估的患者6个月结局的独立危险因素。研究人员还评估了PTCI的发生情况,以及它是否为TBI的国际预后和临床试验设计任务(IMPACT)核心模型和扩展模型增加了增量的预后价值。

研究人员招募了143名患者,其中47名(32.9%)患有PTCI。在多元有序Logistic回归中,PTCI被保留在IMPACT核心和扩展模型中,作为GOS的独立预测因子。当将PTCI添加到IMPACT核心模型中时(AUC=0.73,95%CI为0.66-0.82;增加到AUC=0.79,95%CI为0.71-0.83,p=0.0007)和扩展模型(AUC=0.74,95%CI为0.65-0.81,增加到AUC=0.80;95%CI为0.69-0.85;p=0.00008)预测性能显著提高。PTCI患者表现出较高的ICU死亡率和6个月死亡率,而两组之间的医院死亡率没有差异。

由此可见,PTCI是中度或重度TBI患者常见并发症,并且是长期残疾的独立危险因素。在IMPACT核心和扩展的预测模型中添加PTCI可以显著提高其在预测GOS方面的性能。

原始出处:

Nicola Latronico.et al.Impact of a posttraumatic cerebral infarction on outcome in patients with TBI: the Italian multicenter cohort INCEPT study.Critical Care.2020.https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-2746-5

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    2020-09-10 hxj0117
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    2020-02-08 karmond