Medicine :中国农村老年高血压患者血压应控制在140/90 mmHg以下还是150/90 mmHg以下?

2015-10-30 phylis 译 MedSci原创

JNC-8最近推荐收缩压控制由最初的大于等于150  mmHg,大于60岁患者治疗目标应<150/90 mmHg。然而,一些随机对照试验机观察研究的结果不支持这个推荐。在这项前瞻性队列研究中,5006名中国农村高血压患者,年龄大于等于60岁。校正其他潜在的混杂因素,应用Cox比例风险模型评估随访平均的BP和预后(各种原因及心血管死亡,冠心病的发生及卒中)的相关性,随访时间中位数为4.8年。血

中国第八届全国委员会(JNC-8)最近推荐对于大于60岁高血压患者,当其血压超过150  mmHg的时候开始药物治疗,且血压治疗目标:其血压应控制在<150/90 mmHg。然而,一些随机对照试验机观察研究的结果不支持这个推荐。

在这项前瞻性队列研究中,5006名中国农村高血压患者,年龄大于等于60岁。校正其他潜在的混杂因素,应用Cox比例风险模型评估随访平均的BP和预后(各种原因及心血管死亡、冠心病的发生及卒中)的相关性,随访时间中位数为4.8年。血压(收缩压或舒张压)与不良预后呈上升或J型相关。与血压<140/90 mmHg相比,血压在140-149/<90 mmHg。患者各种原因的死亡率(HR: 2.698; 95% CI: 1.989-3.659),心血管死亡(HR: 2.702; 95% CI: 1.855-3.935),冠心病的发生(HR: 3.263; 95% CI: 2.063-5.161)及卒中(HR: 2.334; 95% CI: 1.559-3.945)显著升高。

老年高血压(140-149/<90 mmHg)患者发生不良预后的风险增加,提示基于JNC-8指南推荐血压控制在140-149/<90 mmHg对中国农村年龄大于60岁的高血压患者可能是不适合的。

原文出处:

Zheng L, Li J, Sun Z, et al. Relationship of Blood Pressure With Mortality and Cardiovascular Events Among Hypertensive Patients aged ≥60 years in Rural Areas of China: A Strobe-Compliant Study.  Medicine (Baltimore).  2015,Sep.


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    2015-12-12 kalseyzl
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    2016-02-21 jeanqiuqiu
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    2015-11-01 daviiliu
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    2015-10-30 梦想天空

    0

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JAMA Surg:减肥术后肥胖相关并发症缓解的临床因素

JAMA Surg:减肥术后肥胖相关并发症缓解的临床因素本研究旨在评估肥胖患者减肥术后其肥胖相关并发症的改善情况,并确定与这些反应相关的临床因素。该项回顾性队列分析研究共纳入了33718名患者,于2005年1月1日至2010年6月30日期间接受了胃旁路术(RYGB)或可调节束带胃捆扎术(AGB)。根据诊断及药物确定患者减肥术前后的合并症。基于患者术前6个月内合并症的记录,而术后18个月却无此合并症

Circulation:他汀或可抑制高血压和糖尿病患者醛固酮的分泌

他汀类药物确实可减少心血管死亡率,并且似乎这种益处是独立于降脂治疗特性的。多国学者近期评估了他汀类药物是否可调节醛固酮的分泌,后者可导致心血管疾病。结果表明,高血压和糖尿病患者应用他汀与醛固酮分泌减少有关,这一影响似乎在使用亲脂性他汀和较大剂量应用者中最为明显。相关论文近期发表于《循环》(Circulation)杂志。 研究者们对两项干预试验中的受试者检测了肾上腺激素。在第一项试验的高血

Lancet Dia& Endo:阿米洛利加氢氯噻嗪,在高血压患者利尿治疗时效果好

由噻嗪类利尿剂导致的缺钾与血液中的血糖升高有关。该研究评估了是否可以通过增加或置换保钾利尿剂,阿米洛利,来与噻嗪类结合治疗预防糖耐量异常,并且改善血压控制。研究人员在英国11个二级和两个初级医疗点做了一项平行组,随机,双盲试验。符合条件的患者年龄在18-80岁;在所允许的背景药物如血管紧张素转换酶抑制剂,血管紧张素受体阻断剂,β受体阻断剂,钙通道阻滞剂,或直接肾素抑制剂(以前未经治疗的患者在特定情

PLoS One:踝臂血压指数小于0.9是发生卒中的独立危险因素?

目的:研究者调查了有卒中史的中国成人中踝臂血压指数(ABI),双臂血压(BP)的差及踝间血压差的相关性。方法:这个研究选取中国高血压研究调查中的1485名受试者,年龄大于35岁。研究者应用示波设备检测四肢血压,并计算ABI及臂间血压差/踝间血压差。应用logistic回归分析评估血压参数和卒中史的其他因素的相关性。结果:在单变量分析中,受试者ABI <0.9,臂间血压差≥15 mmHg及踝间

百万血压筛查工程:中国高血压筛查与防控惠民行动在京启动

10月29日,由中国高血压联盟、北京市高血压防治协会、中国医学科学院生物医学工程研究所、中国老年保健协会保健与长寿专业委员会联合正安(北京)医疗设备有限公司、深圳瑞光康泰科技有限公司、天津善医科技发展有限公司开展“百万血压筛查工程:中国高血压筛查与防控惠民行动”启动仪式在北京国宾酒店隆重举行。来自全国的医学专家、与会企业、嘉宾及媒体的朋友共同见证了这一具有历史意义的重要时刻。 “知晓您的