Crit Care:念珠菌病患者发展为感染性休克的相关因素

2020-04-01 MedSci原创 MedSci原创

年龄和腹部感染源是与感染性休克发生密切相关的重要因素。该研究的结果表明感染性休克的发生与宿主因素和感染源可能比念珠菌固有毒性因素更为重要。

约三分之一的念珠菌病患者会发展为感染性休克。对于为什么有些患者会出现感染性休克,而有些患者不会发生感染性休克的原因尚不明确。近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,该研究通过分析大量念珠菌病患者旨在明确与感染性休克发展相关的因素。

研究人员对来自西班牙和意大利12家医院的两个前瞻性多中心念珠菌病患者队列进行了事后分析。研究人员分析了2016年9月至2018年2月发生的所有事件,以评估根据第三版脓毒症和感染性休克的国际共识定义(Sepsis-3)确定的与感染性休克发展相关的因素。

在317例念珠菌病患者中,99例(31.2%)患者出现了由念珠菌引起的感染性休克。多元Logistic回归分析确定了以下与脓毒性休克发展相关的因素:年龄>50岁(OR为2.57,95%可信区间为1.03-6.41,p=0.04)、腹部感染源(OR为2.18,95%可信区间为1.04-4.55,p=0.04)、念珠菌病发病时入住一般病房(OR为0.21,95%可信区间为0.12-0.44, p=0.001)。感染性休克的发展与30天死亡风险的增加独立相关(OR为2.14, 95%可信区间为1.08-4.24, p=0.02)。

由此可见,年龄和腹部感染源是与感染性休克发生密切相关的重要因素。该研究的结果表明感染性休克的发生与宿主因素和感染源可能比念珠菌固有毒性因素更为重要。

原始出处:

Matteo Bassetti.et al.Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts.Critical Care.2020.https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-2793-y

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    2020-11-19 ms1000001868180773

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