Eur Respir J:阻塞性睡眠呼吸暂停与胸主动脉瘤进展的关系

2020-11-20 MedSci原创 MedSci原创

OSA可能是TAA扩展中等但独立的危险因素,因此可能导致威胁生命的主动脉疾病并发症。

阻塞性睡眠呼吸暂停(OSA)与主动脉瘤的患病率增加相关,并且还提示严重的OSA会进一步加剧腹部动脉瘤的进展。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员旨在评估OSA是否是胸主动脉瘤(TAA)进展的危险因素。

研究人员对TAA患者进行3年以上的年度标准化超声心动图检测升主动脉。该研究的主要结局是相对于呼吸暂停低通气指数(AHI)的TAA扩张率,该研究的次要结局包括监测主动脉事件(破裂、夹层、择期手术和死亡的综合结局)。

2014年7月至2020年3月,共有230名患者(中位年龄为70岁,男性占78%)参加了该队列研究。基线时,34.8%的患者AHI≥15次事件·h-1。在基线时,TAA直径与AHI之间没有关联。3年后,主动脉窦的平均扩张率为0.55±1.25 mm,升主动脉的平均扩张率为0.60±1.12 mm。在回归分析中,控制了基线直径和血管危险因素之后,有强有力的证据表明TAA扩张与AHI呈正相关(主动脉窦估计值为0.025mm(95%CI为0.009至0.040),p<0.001;升主动脉估计值为0.026mm [95%CI为0.011至0.041],p=0.001)。二十名参与者(8%)经历了主动脉事件,但是与OSA的严重程度无关。

由此可见,OSA可能是TAA扩展中等但独立的危险因素,因此可能导致威胁生命的主动脉疾病并发症。

原始出处:

Thomas Gaisl,et al.Obstructive sleep apnea and the progression of thoracic aortic aneurysm: a prospective cohort study.Eur Respir J.2020.https://erj.ersjournals.com/content/early/2020/10/29/13993003.03322-2020

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    2021-03-12 tomyang96
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    2020-11-20 Dr.Yu

    好,學習中

    0

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