BMC Gastroenterology:血清溶血磷脂酶自分泌蛋白(ATX)和溶血磷脂酸(LPA)可以作为胰腺癌潜在诊断生物标志物

2021-02-16 MedSci原创 MedSci原创

在最近几十年中,早期诊断和改良治疗提高了许多癌症的存活率。然而,胰腺癌(PC)仍然是最致命的癌症之一,其预后仍然很差。

      在最近几十年中,早期诊断和改良治疗提高了许多癌症的存活率。然而,胰腺癌(PC)仍然是最致命的癌症之一,其预后仍然很差。在具有可切除肿瘤的患者中,PC的5年生存率范围为15%至20%。对于那些表现为无法切除的肿瘤和远处转移的PC患者,其5年生存率接近0%。这种不良的预后和低的存活率主要是由于缺乏可识别的症状和早期检测标记物导致诊断延迟造成的。因此,学界迫切需要能够早期检测PC并减少转移可能性的新生物标记的发现。

 

 

      溶血磷脂酶自分泌蛋白(ATX)及其产物溶血磷脂酸(LPA)在PC患者的疾病进展中起着至关重要的作用,并与几种癌症的发病率增加相关。体外和体内研究表明,升高的ATX-LPA信号转导活性可能有助于癌症的进展和开始。但是,尚不清楚血浆ATX和LPA是否可以作为PC的诊断生物标志物。在这项研究中,研究人员评估了血浆LPA和ATX作为癌症生物标志物的潜力。

 

 

      研究人员从114名PC患者,120名健康志愿者和4名胰腺良性疾病患者中获得血清,并进行ELISA检测评估ATX,LPA和CA19-9的水平。然后进行统计学分析。

 

 

 

      研究结果显示PC患者的血清ATX,LPA和CA19-9水平明显高于BPD患者或HVs(p <0.001)。LPA在鉴别早期PC中的敏感性为91.74%,ATX的特异性为80%。与BPD患者和HV患者血清中的水平相比,早期PC患者中ATX,LPA和CA19-9的水平均明显更高。通过添加ATX和LPA,CA19-9对PC的诊断功效得到了显着增强(p = 0.0012)。

 

 

      本项研究通过实验证明:对患者进行LPA和ATX水平以及CA19-9水平的测量可用于PC的早期检测和诊断。

 

 

原始出处:

Jiang Chen. Et al. Evaluation of serum ATX and LPA as potential diagnostic biomarkers in patients with pancreatic cancer.BMC Gastroenterology.2021.

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    2021-09-05 许安
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1841644, encodeId=5c45184164443, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon May 31 19:22:03 CST 2021, time=2021-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712698, encodeId=45231e12698ed, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1841644, encodeId=5c45184164443, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon May 31 19:22:03 CST 2021, time=2021-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712698, encodeId=45231e12698ed, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, 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  7. 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胰腺癌是目前死亡率最高的癌症之一,具有广泛转移的特点,绝大部分患者在确诊时已是晚期。上皮间质转换(EMT)的可塑性通过维持EMT和MET状态之间的转换,在肿瘤的进展和转移中起着关键作用。本研究目的是了