Hypertension:高血压与感染性心内膜炎的关系

2022-05-13 MedSci原创 MedSci原创

血压升高被确定以剂量依赖性方式作为感染性心内膜炎的危险因素。高血压作为罕见感染性心脏病的危险因素,增加了公共卫生保健负担。

感染性心内膜炎是一种罕见的疾病,会导致严重的并发症,如心力衰竭、感染性栓塞、卒中和器官衰竭。感染性心内膜炎的住院死亡率约为20%。众所周知,感染性心内膜炎在发达国家的年发病率稳定在每100000人中3-7人。然而,最近的报告显示其发病率在增加。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,该研究利用了国民健康保险服务数据库,通过调查不同血压水平的患者感染性心内膜炎的发生率,来评估高血压与感染性心内膜炎之间的相关性。

研究人员检索了2009年与健康筛查数据库相关的4080331名受试者的数据(男性占55.08%;平均年龄为47.12±14.13岁)。从2009年到2018年,研究人员对感染性心内膜炎首发的危险因素进行了调查。高血压分为血压正常、高血压前期、高血压和服药后的高血压。Cox比例风险模型评估健康筛查期间血压水平对感染性心内膜炎的影响。

在9年的随访中,812名参与者(0.02%)被诊断为感染性心内膜炎。血压正常组、高血压前期组、高血压组和高血压药物治疗组感染性心内膜炎发生率分别为0.9、1.4、2.6和6.0/10万人每年。与血压正常组相比,高血压前期、高血压和高血压伴用药组感染性心内膜炎风险以剂量反应方式增加(发别的风险比为1.33[95%CI为1.06-1.68];风险比为1.98[1.48-2.66];风险比为2.56[2.02-3.24],均P<0.001)。

由此可见,在这项平均随访9年的大型国家队列研究中,血压升高被确定以剂量依赖性方式作为感染性心内膜炎的危险因素。高血压作为罕见感染性心脏病的危险因素,增加了公共卫生保健负担。

原始出处:

Gyu Bae Lee.et al.Association Between Hypertension and Incident Infective Endocarditis.Hypertension.2022.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.19185

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    2022-07-26 feather89
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    2022-07-19 Doctoryangbai

    一定要做好高血压的防治

    0

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    2022-05-16 1355517cm30暂无昵称

    0

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