Transl Psychiatry:压力催人老,放松保健康

2021-12-12 “生物世界”公众号 “生物世界”公众号

随着生活节奏的加快,人们的压力也在变得越来越大。早期的研究表明,压力会导致脱发、白发、肥胖等危害。长期压力会导致一系列健康问题,包括心脏病、糖尿病、抑郁和焦虑。不仅如此,压力还会抑制免疫功能,减弱抵御

随着生活节奏的加快,人们的压力也在变得越来越大。早期的研究表明,压力会导致脱发、白发、肥胖等危害。长期压力会导致一系列健康问题,包括心脏病、糖尿病、抑郁和焦虑。不仅如此,压力还会抑制免疫功能,减弱抵御能力,甚至是促进肿瘤生长。

近日,美国耶鲁大学的研究人员在 Translational Psychiatry 期刊上发表了一篇题为:Psychological and biological resilience modulates the effects of stress on epigenetic aging 的研究论文。

该研究表明,压力会加速衰老,但是,可以通过加强情绪调节和自我控制来最大程度地减少压力的这些不利后果。

近年来,科学家通过追踪DNA中的化学变化,找到了测量生物年龄的方法。DNA中的化学变化是随着年龄的增长而自然发生的,但在不同的人群中发生的时间不同。事实证明,这些所谓的“表观遗传时钟”比实际年龄更能预测寿命和健康。

GrimAge时钟,是一种表观遗传时钟,旨在根据细胞的甲基化模式预测个人的剩余寿命。

在该研究中,研究人员招募了444名年龄在19-50岁之间的参与者,参与人员提供了用于评估GrimAge捕获的与年龄相关的化学变化以及其他健康标志物的血液样本,还回答了旨在揭示压力水平和心理弹性的问题。

研究发现,那些在慢性压力相关指标上得分高的人,表现出加速衰老标志物和生理变化,如胰岛素抵抗增加。

压力与GrimAge加速相关

意外的是,压力并没有对每个人的健康产生同等程度的影响。在情绪调节和自我控制上得分高的参与者,分别对压力对衰老和胰岛素抵抗的影响更具弹性。

心理弹性因素缓和压力对GrimAge加速的影响

该研究表明,压力确实会加速衰老,但他们也提出了一种有希望的方法,可以通过加强情绪调节和自我控制来最大程度地减少压力的这些不利后果。

研究人员表示,参与者的心理弹性越强,他们活得更长寿、更健康的可能性就越大。

所以,就像掌控自己的命运一样,掌控自己的情绪依然很重要。

原始出处:

Harvanek, Z.M., Fogelman, N., Xu, K. et al. Psychological and biological resilience modulates the effects of stress on epigenetic aging. Transl Psychiatry 11, 601 (2021). https://doi.org/10.1038/s41398-021-01735-7.

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  5. 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objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d7c1341677, createdName=50277, createdTime=Mon Dec 13 07:02:23 CST 2021, time=2021-12-13, status=1, ipAttribution=)]
    2021-12-14 ms1000000203803067

    学到了

    0

  6. 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channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/17/e1e40fbfe4726f48245971c059256779.jpg, createdBy=8a582050189, createdName=heyuzhou520, createdTime=Tue Dec 14 06:34:19 CST 2021, time=2021-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079701, encodeId=a3ef10e970176, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Mon Dec 13 21:31:24 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079670, encodeId=b30c10e967079, content=坚持学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Mon Dec 13 20:16:09 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079485, encodeId=e63810e94854a, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=3e642424157, createdName=123a16c8m00暂无昵称, createdTime=Mon Dec 13 10:52:02 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079400, encodeId=699010e940072, content=身心健康的表现, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d7c1341677, createdName=50277, createdTime=Mon Dec 13 07:02:23 CST 2021, time=2021-12-13, status=1, ipAttribution=)]
    2021-12-14 heyuzhou520

    笑一笑十年少

    0

  7. 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channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/17/e1e40fbfe4726f48245971c059256779.jpg, createdBy=8a582050189, createdName=heyuzhou520, createdTime=Tue Dec 14 06:34:19 CST 2021, time=2021-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079701, encodeId=a3ef10e970176, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Mon Dec 13 21:31:24 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079670, encodeId=b30c10e967079, 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objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d7c1341677, createdName=50277, createdTime=Mon Dec 13 07:02:23 CST 2021, time=2021-12-13, status=1, ipAttribution=)]
    2021-12-13 医鸣惊人

    认真学习了。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1792299, encodeId=c4f21e9229986, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Tue Nov 01 01:45:17 CST 2022, time=2022-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657585, encodeId=2199165e5851d, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, 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channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/17/e1e40fbfe4726f48245971c059256779.jpg, createdBy=8a582050189, createdName=heyuzhou520, createdTime=Tue Dec 14 06:34:19 CST 2021, time=2021-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079701, encodeId=a3ef10e970176, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Mon Dec 13 21:31:24 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079670, encodeId=b30c10e967079, content=坚持学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Mon Dec 13 20:16:09 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079485, encodeId=e63810e94854a, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=3e642424157, createdName=123a16c8m00暂无昵称, createdTime=Mon Dec 13 10:52:02 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079400, encodeId=699010e940072, content=身心健康的表现, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d7c1341677, createdName=50277, createdTime=Mon Dec 13 07:02:23 CST 2021, time=2021-12-13, status=1, ipAttribution=)]
    2021-12-13 SR~young海东

    坚持学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1792299, encodeId=c4f21e9229986, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Tue Nov 01 01:45:17 CST 2022, time=2022-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657585, encodeId=2199165e5851d, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, 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channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/17/e1e40fbfe4726f48245971c059256779.jpg, createdBy=8a582050189, createdName=heyuzhou520, createdTime=Tue Dec 14 06:34:19 CST 2021, time=2021-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079701, encodeId=a3ef10e970176, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Mon Dec 13 21:31:24 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079670, encodeId=b30c10e967079, content=坚持学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Mon Dec 13 20:16:09 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079485, encodeId=e63810e94854a, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=3e642424157, createdName=123a16c8m00暂无昵称, createdTime=Mon Dec 13 10:52:02 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079400, encodeId=699010e940072, content=身心健康的表现, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d7c1341677, createdName=50277, createdTime=Mon Dec 13 07:02:23 CST 2021, time=2021-12-13, status=1, ipAttribution=)]
    2021-12-13 123a16c8m00暂无昵称

    受益匪浅

    0

  10. 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content=坚持学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Mon Dec 13 20:16:09 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079485, encodeId=e63810e94854a, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=3e642424157, createdName=123a16c8m00暂无昵称, createdTime=Mon Dec 13 10:52:02 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079400, encodeId=699010e940072, content=身心健康的表现, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d7c1341677, createdName=50277, createdTime=Mon Dec 13 07:02:23 CST 2021, time=2021-12-13, status=1, ipAttribution=)]
    2021-12-13 50277

    身心健康的表现

    0

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