Sci Rep:研究揭示绿茶对口腔上皮细胞miRNA和微生物的影响

2018-05-10 MedSci MedSci原创

绿茶(GT)提取物或纯化儿茶素具有预防口腔癌和其他癌症并抑制啮齿动物模型中癌症进展的能力,但在人类中的作用存在争议。本研究旨在通过检查其对口腔上皮细胞的影响来了解对GT可变反应的来源。吸烟接触4周前后,测量吸烟者舌下上皮细胞RNA和舌和牙龈微生物群。GT消耗对口腔上皮中的miRNA表达产生不一致的影响。只有分析检验配对的miRNAs,显示GT暴露后发生变化和一致的表达,为GT对miRNA的影响提供

绿茶(GT)提取物或纯化儿茶素具有预防口腔癌和其他癌症并抑制啮齿动物模型中癌症进展的能力,但在人类中的作用存在争议。本研究旨在通过检查其对口腔上皮细胞的影响来了解对GT可变反应的来源。

吸烟接触4周前后,测量吸烟者舌下上皮细胞RNA和舌和牙龈微生物群。GT消耗对口腔上皮中的miRNA表达产生不一致的影响。只有分析检验配对的miRNAs,显示GT暴露后发生变化和一致的表达,为GT对miRNA的影响提供了证据,鉴定了与两个中心共同表达的miR-181a-5p和miR-301a-3p。相比之下,易患癌症的舌粘膜的微生物组的检查显示,链球菌和葡萄球菌以及GT暴露后的其他属的相对丰度发生明显变化。

这些数据支持茶消费能持续改变人类口腔细菌的观点,但是GT对人类口腔上皮miRNA表达的影响因人而异。

原始出处:

Guy R. Adami, Christy C. Tangney, et al., Effects of green tea on miRNA and microbiome of oral epithelium. Sci Rep. 2018; 8: 5873. doi:  10.1038/s41598-018-22994-3

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    2018-12-29 smallant2002
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    2018-05-12 Homburg
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    2018-05-12 hbwxf
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