Clini Trans Gastroenterology: 激活素A可调节急性胰腺炎的炎症反应并预测疾病预后

2020-05-03 MedSci原创 MedSci原创

急性胰腺炎(AP)的死亡率很高,目前的治疗仅限于支持治疗,因此,非常需要研究疾病驱动因素和预后指标。激活素A是一种炎症反应介质,其血清水平与AP严重程度相关。

背景及目的: 急性胰腺炎(AP)的死亡率很高,目前的治疗仅限于支持治疗,因此,非常需要研究疾病驱动因素和预后指标。激活素A是一种炎症反应介质,其血清水平与AP严重程度相关。本项研究旨在探究激活素A是否可以独立于体重指数(BMI)并作为AP炎症反应的靶向启动因子。

方法: 研究人员通过评估患者BMI和血清激活素A水平以确定一群AP患者的疾病严重程度。为了评估激活素A的抑制作用,研究人员使用了铜蓝蛋白诱导的小鼠AP模型,并在AP发生之前和过程中用激活素A特异性中和抗体或免疫球蛋白G对照治疗了小鼠。最后,研究人员测量了胰腺和巨噬细胞细胞系对活化素A的产生和释放,并观察了活化素A处理后巨噬细胞的活化情况。

结果: BMI和激活素A可以独立预测患者的AP严重程度。在AP小鼠中抑制激活素A可降低疾病严重程度和局部免疫细胞浸润。炎症刺激导致胰腺细胞激活蛋白A的产生和释放,但巨噬细胞却没有。巨噬细胞被激活素A激活,这表明激活素A可能会响应损伤而促进胰腺炎症。

讨论: 激活素A提供了急性胰腺炎治疗靶点,因为它可中断AP进展中的炎症循环和组织损伤。而且,评估入院患者的激活素A和BMI可以为筛查可能发展为严重疾病的患者提供重要的预测价值。

原始出处:

Thomas, Alexandra L. et al. Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index. Clini Trans Gastroenterology.2020.

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    2021-01-31 bsmagic9140
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    2021-03-03 许安
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    2020-12-08 徐岩
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2020, time=2020-05-05, status=1, ipAttribution=)]
  5. 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2020, time=2020-05-05, status=1, ipAttribution=)]
  6. 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  7. 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href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Tue May 05 07:52:03 CST 2020, time=2020-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505004, encodeId=4bba150500435, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue May 05 07:52:03 CST 2020, time=2020-05-05, status=1, ipAttribution=)]
    2020-05-07 wxl882001

    了解一下

    0

  8. 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