JAMA Dermatol:西罗莫司治疗儿童血管畸形的效果

2021-09-22 Nebula MedSci原创

纯淋巴管畸形可能是西罗莫司治疗的最佳指征

西罗莫司又称为雷帕霉素,是一种大环内酯类的抗生素免疫抑制剂,临床上主要用于治疗肾移植的患者,避免因器官移植出现排斥反应。目前,西罗莫司越来越多地被用于治疗各种血管异常,尽管缺乏其有效性的证据。

本研究旨在评估西罗莫司对儿童慢血流血管畸形的疗效和安全性,以更好地界定治疗指征。

这是一项多中心、开放标签的、观察性、随机临床试验,在2015年9月25日至2018年3月22日期间,从法国的11家医院招募了59位6-18岁的慢血流血管畸形的患儿。患儿经历了观察期(OP),然后在接受口服西罗莫司治疗后转入介入期(IP)。转换时间从第 4 个月随机分组到第 8 个月,每个患者的整个研究期持续 12 个月。患儿接受了三次 MRI 检查:基线(MO)、从 OP 转入 IP 时(MS)和随访结束时(M12)。主要结果是每单位时间 MRI 检测到的血管畸形体积的变化。次要结果包括主观终点:疼痛、出血、渗出、生活质量和安全性。

所有血管畸形和静脉畸形患儿的疼痛和疗效

在这 59 位受试患儿(35 位女孩;平均 11.6 岁)中,22 位(37.3%)有纯静脉畸形,18 位(30.5%)有囊性淋巴管畸形,19 位(32.2%) 为复合畸形,包括综合征形式。总体上,血管畸形体积的变化介入期和观察期之间没有显著差异(所有血管畸形、静脉畸形和复合畸形的平均差分别是 –0.001、0.001和0.001)。

纯淋巴管畸形儿童的疼痛和疗效

但是,纯淋巴管畸形儿童的畸形淋巴管体积显著减少(平均差 -0.005)。总体上,西罗莫司对疼痛有积极作用,特别是对于复合畸形,以及出血、渗出、自我评估疗效和生活质量。在西罗莫司治疗期间,56 位患儿发生了 231 例不良事件(5 例严重不良事件,无致命性)。最常见的不良事件是口腔溃疡(49.2%)。

不良事件

综上所述,纯淋巴管畸形似乎是西罗莫司治疗的最佳指征,西罗莫司治疗不仅可缩小畸形淋巴管的体积,还可改善渗出、出血及生活质量。西罗莫司治疗可显著减轻复合畸形患儿的疼痛、渗出和出血。纯静脉畸形患儿从西罗莫司治疗中的获益少于另两个亚组。

原始出处:

Maruani A, Tavernier E, Boccara O, et al. Sirolimus (Rapamycin) for Slow-Flow Malformations in Children: The Observational-Phase Randomized Clinical PERFORMUS Trial. JAMA Dermatol. Published online September 15, 2021. doi:10.1001/jamadermatol.2021.3459

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    2021-09-24 wushaoling
  4. [GetPortalCommentsPageByObjectIdResponse(id=1709735, encodeId=e08f1e09735b6, content=<a href='/topic/show?id=28e089e13d1' target=_blank style='color:#2F92EE;'>#血管畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89713, encryptionId=28e089e13d1, topicName=血管畸形)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70cd31776816, createdName=12498ca5m93暂无昵称, createdTime=Tue Nov 16 06:41:12 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340053, encodeId=9cc81340053bf, content=<a href='/topic/show?id=8c519053e85' target=_blank style='color:#2F92EE;'>#西罗莫司#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90537, encryptionId=8c519053e85, topicName=西罗莫司)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/JHX80Wpw3cstP6RtQ1pO8asyNiah0uIJwh7hmKm1emARpicBibTeQrj1SN7YwGSwibOrIL2kZ9WHmRiaznSnuHhUJUg/132, createdBy=c7de2500155, createdName=ms3415360956839622, createdTime=Fri Sep 24 12:41:12 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362353, encodeId=80f313623530d, content=<a href='/topic/show?id=9857e03444b' target=_blank style='color:#2F92EE;'>#畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70344, encryptionId=9857e03444b, topicName=畸形)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Fri Sep 24 12:41:12 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054061, encodeId=99d31054061cf, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Thu Sep 23 09:24:41 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054009, encodeId=8271105400948, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Thu Sep 23 06:46:45 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053990, encodeId=a4d2105399059, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211009/0ae31fdf59e2426db40ceac2aaa8f957/acd095b2a61d462f92190dc941c830f8.jpg, createdBy=51fa5536016, createdName=公子墨, createdTime=Thu Sep 23 01:08:55 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053955, encodeId=40ca105395502, content=学习效果好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2f255526204, createdName=我思故我在2, createdTime=Wed Sep 22 23:10:53 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053947, encodeId=489d105394e7c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd4f2966483, createdName=804605908, createdTime=Wed Sep 22 22:57:18 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053936, encodeId=67a3105393622, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Wed Sep 22 21:50:24 CST 2021, time=2021-09-22, status=1, ipAttribution=)]
    2021-09-23 智慧药

    学习学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1709735, encodeId=e08f1e09735b6, content=<a href='/topic/show?id=28e089e13d1' target=_blank style='color:#2F92EE;'>#血管畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89713, encryptionId=28e089e13d1, topicName=血管畸形)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70cd31776816, createdName=12498ca5m93暂无昵称, createdTime=Tue Nov 16 06:41:12 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340053, encodeId=9cc81340053bf, content=<a href='/topic/show?id=8c519053e85' target=_blank style='color:#2F92EE;'>#西罗莫司#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90537, encryptionId=8c519053e85, topicName=西罗莫司)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/JHX80Wpw3cstP6RtQ1pO8asyNiah0uIJwh7hmKm1emARpicBibTeQrj1SN7YwGSwibOrIL2kZ9WHmRiaznSnuHhUJUg/132, createdBy=c7de2500155, createdName=ms3415360956839622, createdTime=Fri Sep 24 12:41:12 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362353, encodeId=80f313623530d, content=<a href='/topic/show?id=9857e03444b' target=_blank style='color:#2F92EE;'>#畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70344, encryptionId=9857e03444b, topicName=畸形)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Fri Sep 24 12:41:12 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054061, encodeId=99d31054061cf, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Thu Sep 23 09:24:41 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054009, encodeId=8271105400948, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Thu Sep 23 06:46:45 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053990, encodeId=a4d2105399059, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211009/0ae31fdf59e2426db40ceac2aaa8f957/acd095b2a61d462f92190dc941c830f8.jpg, createdBy=51fa5536016, createdName=公子墨, createdTime=Thu Sep 23 01:08:55 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053955, encodeId=40ca105395502, content=学习效果好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2f255526204, createdName=我思故我在2, createdTime=Wed Sep 22 23:10:53 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053947, encodeId=489d105394e7c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd4f2966483, createdName=804605908, createdTime=Wed Sep 22 22:57:18 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053936, encodeId=67a3105393622, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Wed Sep 22 21:50:24 CST 2021, time=2021-09-22, status=1, ipAttribution=)]
    2021-09-23 学医无涯

    学习一下

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1709735, encodeId=e08f1e09735b6, content=<a href='/topic/show?id=28e089e13d1' target=_blank style='color:#2F92EE;'>#血管畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89713, encryptionId=28e089e13d1, topicName=血管畸形)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70cd31776816, createdName=12498ca5m93暂无昵称, createdTime=Tue Nov 16 06:41:12 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340053, encodeId=9cc81340053bf, content=<a href='/topic/show?id=8c519053e85' target=_blank style='color:#2F92EE;'>#西罗莫司#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90537, encryptionId=8c519053e85, topicName=西罗莫司)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/JHX80Wpw3cstP6RtQ1pO8asyNiah0uIJwh7hmKm1emARpicBibTeQrj1SN7YwGSwibOrIL2kZ9WHmRiaznSnuHhUJUg/132, createdBy=c7de2500155, createdName=ms3415360956839622, createdTime=Fri Sep 24 12:41:12 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362353, encodeId=80f313623530d, content=<a href='/topic/show?id=9857e03444b' target=_blank style='color:#2F92EE;'>#畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70344, encryptionId=9857e03444b, topicName=畸形)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Fri Sep 24 12:41:12 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054061, encodeId=99d31054061cf, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Thu Sep 23 09:24:41 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054009, encodeId=8271105400948, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Thu Sep 23 06:46:45 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053990, encodeId=a4d2105399059, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211009/0ae31fdf59e2426db40ceac2aaa8f957/acd095b2a61d462f92190dc941c830f8.jpg, createdBy=51fa5536016, createdName=公子墨, createdTime=Thu Sep 23 01:08:55 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053955, encodeId=40ca105395502, content=学习效果好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2f255526204, createdName=我思故我在2, createdTime=Wed Sep 22 23:10:53 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053947, encodeId=489d105394e7c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd4f2966483, createdName=804605908, createdTime=Wed Sep 22 22:57:18 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053936, encodeId=67a3105393622, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Wed Sep 22 21:50:24 CST 2021, time=2021-09-22, status=1, ipAttribution=)]
    2021-09-23 公子墨

    非常棒

    0

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    2021-09-22 我思故我在2

    学习效果好

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  8. [GetPortalCommentsPageByObjectIdResponse(id=1709735, encodeId=e08f1e09735b6, content=<a href='/topic/show?id=28e089e13d1' target=_blank style='color:#2F92EE;'>#血管畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89713, encryptionId=28e089e13d1, topicName=血管畸形)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70cd31776816, createdName=12498ca5m93暂无昵称, createdTime=Tue Nov 16 06:41:12 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340053, encodeId=9cc81340053bf, content=<a href='/topic/show?id=8c519053e85' target=_blank style='color:#2F92EE;'>#西罗莫司#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90537, encryptionId=8c519053e85, topicName=西罗莫司)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/JHX80Wpw3cstP6RtQ1pO8asyNiah0uIJwh7hmKm1emARpicBibTeQrj1SN7YwGSwibOrIL2kZ9WHmRiaznSnuHhUJUg/132, createdBy=c7de2500155, createdName=ms3415360956839622, createdTime=Fri Sep 24 12:41:12 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362353, encodeId=80f313623530d, content=<a href='/topic/show?id=9857e03444b' target=_blank style='color:#2F92EE;'>#畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70344, encryptionId=9857e03444b, topicName=畸形)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Fri Sep 24 12:41:12 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054061, encodeId=99d31054061cf, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Thu Sep 23 09:24:41 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054009, encodeId=8271105400948, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Thu Sep 23 06:46:45 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053990, encodeId=a4d2105399059, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211009/0ae31fdf59e2426db40ceac2aaa8f957/acd095b2a61d462f92190dc941c830f8.jpg, createdBy=51fa5536016, createdName=公子墨, createdTime=Thu Sep 23 01:08:55 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053955, encodeId=40ca105395502, content=学习效果好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2f255526204, createdName=我思故我在2, createdTime=Wed Sep 22 23:10:53 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053947, encodeId=489d105394e7c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd4f2966483, createdName=804605908, createdTime=Wed Sep 22 22:57:18 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053936, encodeId=67a3105393622, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Wed Sep 22 21:50:24 CST 2021, time=2021-09-22, status=1, ipAttribution=)]
    2021-09-22 804605908

    学习

    0

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    2021-09-22 仁术2021

    不错

    0

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