Gastroenterology:Barrett食管患者疾病进展评估模型

2017-12-26 zhangfan MedSci原创

研究认为,男性、吸烟、Barrett食管长度以及基线低度异型增生与Barrett食管患者疾病进展相关

Barrett食管患者(BE)发展为高级别异型增生(HGD)和食管腺癌(EAC)风险评估模型研究尚不充分。近日研究人员通过考察人口统计数据、内镜下指数以及内镜-组织学检查结果,开发并验证了BE患者HGD或EAC进展模型。

研究人员对6个医疗中心,1985-2014年间所有BE患者数据进行纵向调查。排除标准包括:随访期少于1年、1年内诊断HGD或EAC、缺少基线组织学数据以及无肠化生。余下患者中,70%用于模型建立,30%用于模型确证。研究的主要终点是随访期间(5.9 年) HGD 或EAC。

2697名患者参与研究,其中男性占84.1%,平均年龄55.4岁,体重指数27.9,平均BE长度3.7 cm。在随访期间,154人(5.7%)发展为HGD或 EAC,年进展率为0.95%。男性、吸烟、BE长度以及基线低度异型增生与疾病进展相关。BE患者进展评估的C指数为0.76 (95% CI,0.72-0.80),校准斜率为0.9966。

研究认为,男性、吸烟、Barrett食管长度以及基线低度异型增生与Barrett食管患者疾病进展相关。

原始出处:


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    2018-05-09 ysjykql
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    2018-10-07 许安
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    2018-01-02 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2017-12-31 虈亣靌

    学习了谢谢作者分享!

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Dec 28 01:43:00 CST 2017, time=2017-12-28, status=1, ipAttribution=)]
    2017-12-28 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2017-12-28 zhouqu_8

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