J Gastroenterology:质子泵抑制剂使用对艰难梭菌感染风险的影响

2019-06-26 不详 MedSci原创

虽然有几项关于质子泵抑制剂(PPIs)使用与艰难梭菌感染(CDI)风险增加之间关联的研究,但缺乏详细研究分析PPI使用对CDI风险的影响。本研究调查了PPI的剂量,持续时间和类型与CDI风险之间的关系。

背景
虽然有几项关于质子泵抑制剂(PPIs)使用与艰难梭菌感染(CDI)风险增加之间关联的研究,但缺乏详细研究分析PPI使用对CDI风险的影响。本研究调查了PPI的剂量,持续时间和类型与CDI风险之间的关系。

方法
研究人员对住院的患者进行了一项单中心队列研究。暴露的队列包括在研究期间至少有一次处方PPI的患者,并且通过随机分配指数来构建对照组,该组患者不使用PPI。

结果
PPI的使用将CDI的风险增加1.8倍[95%置信区间(CI)1.5-2.2]。埃索美拉唑(95%CI 1.4-2.2)的CDI风险增加1.8倍,泮托拉唑的风险增加2.0倍(95%CI 1.5-2.8)。使用高剂量的患者比使用中等剂量的患者具有更高的风险[校正风险比(HR)2.0对1.3]。当PPI暴露期为6天或短于6天时,CDI的风险增加4.2倍。

结论
PPI的使用与发生CDI感染的风险增加相关,并且CDI的风险是剂量依赖性的。

原始出处:

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    2019-07-12 jklm09
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    2020-01-29 许安
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