Mov Disord:帕金森病常见视觉障碍,提示预后不良

2020-07-16 MedSci原创 MedSci原创

在普通人群中,视觉障碍与髋部骨折、抑郁症、焦虑和痴呆相关,多种导致视觉障碍的原因通过早期发现是可以预防或治疗的。然而,与视觉障碍相关的患病率、预后和医疗保健模式尚未在帕金森病(PD)中进行过研究。

背景:在普通人群中,视觉障碍与髋部骨折、抑郁症、焦虑和痴呆相关,多种导致视觉障碍的原因通过早期发现是可以预防或治疗的。然而,与视觉障碍相关的患病率、预后和医疗保健模式尚未在帕金森病(PD)中进行过研究。

方法:Hamedani等对2014年所有医疗保险受益人进行了横断面分析,并对2010-2014年帕金森病患者进行了纵向分析。使用诊断和程序代码来识别帕金森病、视觉障碍、眼科检查、髋部骨折和神经精神障碍。

结果:在2014年的26,209,997名医疗保险受益人中,PD患者的视力障碍发生率(1.7%)明显高于非PD患者(0.71%)(校正优势比 1.60;95% CI 1.56-1.65)。在542,224名患有帕金森病的医疗保险受益人的纵向队列中,只有不到60%的人进行了年度视力检查。此外,视力障碍还与抑郁症(HR 1.23,95% CI 1.14-1.32)、焦虑(HR 1.34,95% CI 1.24-1.43)、痴呆症(HR 1.28,95% CI 1.21-1.36)和死亡(HR 1.49,95% CI 1.44-1.55)的风险增加有关。

结论:视力障碍在帕金森病患者中比普通人群更为常见,并且与阴性的帕金森病相关预后相关。了解这些相关机制有助于指导未来的干预措施,进而改善帕金森病的健康预后。

原始出处:

Hamedani Ali G,Abraham Danielle S,Maguire Maureen G et al. Visual Impairment Is More Common in Parkinson's Disease and Is a Risk Factor for Poor Health Outcomes. Mov. Disord., July 14,2020.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1661285, encodeId=aca51661285bf, content=<a href='/topic/show?id=39c79088173' target=_blank style='color:#2F92EE;'>#视觉障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90881, encryptionId=39c79088173, topicName=视觉障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a4c25257079, createdName=12498484m54(暂无昵称), createdTime=Tue Jul 21 21:45:55 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784426, encodeId=c5751e8442643, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Mon May 10 10:45:55 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013423, encodeId=5b302013423c3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Aug 17 23:45:55 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804698, encodeId=dff9804698f5, content=<a href='/topic/show?id=2b3910085190' target=_blank style='color:#2F92EE;'>#风险#</a>帕金森病和视觉障碍本来是两个不同领域的,但是他们之间的关联可能非常有价值。, beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100851, encryptionId=2b3910085190, topicName=风险)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jul 27 09:15:18 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481131, encodeId=3f631481131df, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Sat Jul 18 06:45:55 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488371, encodeId=8b3f14883e1ab, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Sat Jul 18 06:45:55 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
    2021-05-10 cmsvly
  3. [GetPortalCommentsPageByObjectIdResponse(id=1661285, encodeId=aca51661285bf, content=<a href='/topic/show?id=39c79088173' target=_blank style='color:#2F92EE;'>#视觉障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90881, encryptionId=39c79088173, topicName=视觉障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a4c25257079, createdName=12498484m54(暂无昵称), createdTime=Tue Jul 21 21:45:55 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784426, encodeId=c5751e8442643, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Mon May 10 10:45:55 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013423, encodeId=5b302013423c3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Aug 17 23:45:55 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804698, encodeId=dff9804698f5, content=<a href='/topic/show?id=2b3910085190' target=_blank style='color:#2F92EE;'>#风险#</a>帕金森病和视觉障碍本来是两个不同领域的,但是他们之间的关联可能非常有价值。, beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100851, encryptionId=2b3910085190, topicName=风险)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jul 27 09:15:18 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481131, encodeId=3f631481131df, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Sat Jul 18 06:45:55 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488371, encodeId=8b3f14883e1ab, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Sat Jul 18 06:45:55 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1661285, encodeId=aca51661285bf, content=<a href='/topic/show?id=39c79088173' target=_blank style='color:#2F92EE;'>#视觉障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90881, encryptionId=39c79088173, topicName=视觉障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a4c25257079, createdName=12498484m54(暂无昵称), createdTime=Tue Jul 21 21:45:55 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784426, encodeId=c5751e8442643, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Mon May 10 10:45:55 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013423, encodeId=5b302013423c3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Aug 17 23:45:55 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804698, encodeId=dff9804698f5, content=<a href='/topic/show?id=2b3910085190' target=_blank style='color:#2F92EE;'>#风险#</a>帕金森病和视觉障碍本来是两个不同领域的,但是他们之间的关联可能非常有价值。, beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100851, encryptionId=2b3910085190, topicName=风险)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jul 27 09:15:18 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481131, encodeId=3f631481131df, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Sat Jul 18 06:45:55 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488371, encodeId=8b3f14883e1ab, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Sat Jul 18 06:45:55 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
    2020-07-27 lovetcm

    #风险#帕金森病和视觉障碍本来是两个不同领域的,但是他们之间的关联可能非常有价值。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1661285, encodeId=aca51661285bf, content=<a href='/topic/show?id=39c79088173' target=_blank style='color:#2F92EE;'>#视觉障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90881, encryptionId=39c79088173, topicName=视觉障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a4c25257079, createdName=12498484m54(暂无昵称), createdTime=Tue Jul 21 21:45:55 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784426, encodeId=c5751e8442643, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Mon May 10 10:45:55 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013423, encodeId=5b302013423c3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Aug 17 23:45:55 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804698, encodeId=dff9804698f5, content=<a href='/topic/show?id=2b3910085190' target=_blank style='color:#2F92EE;'>#风险#</a>帕金森病和视觉障碍本来是两个不同领域的,但是他们之间的关联可能非常有价值。, beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100851, encryptionId=2b3910085190, topicName=风险)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jul 27 09:15:18 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481131, encodeId=3f631481131df, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Sat Jul 18 06:45:55 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488371, encodeId=8b3f14883e1ab, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Sat Jul 18 06:45:55 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
    2020-07-18 zywlvao
  6. [GetPortalCommentsPageByObjectIdResponse(id=1661285, encodeId=aca51661285bf, content=<a href='/topic/show?id=39c79088173' target=_blank style='color:#2F92EE;'>#视觉障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90881, encryptionId=39c79088173, topicName=视觉障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a4c25257079, createdName=12498484m54(暂无昵称), createdTime=Tue Jul 21 21:45:55 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784426, encodeId=c5751e8442643, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Mon May 10 10:45:55 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013423, encodeId=5b302013423c3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Aug 17 23:45:55 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804698, encodeId=dff9804698f5, content=<a href='/topic/show?id=2b3910085190' target=_blank style='color:#2F92EE;'>#风险#</a>帕金森病和视觉障碍本来是两个不同领域的,但是他们之间的关联可能非常有价值。, beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100851, encryptionId=2b3910085190, topicName=风险)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jul 27 09:15:18 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481131, encodeId=3f631481131df, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Sat Jul 18 06:45:55 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488371, encodeId=8b3f14883e1ab, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Sat Jul 18 06:45:55 CST 2020, time=2020-07-18, status=1, ipAttribution=)]

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