Hum Vaccin Immunother:研究人员新研制的IIV4疫苗可用于预防≥60岁老年人的季节性流感

2022-05-27 sunshine MedSci原创

随着老年人口的增长,对合适的流感疫苗的需求也在增加。为了控制老年人的季节性流感疫情,研究人员生产了一种由A和B系组成的四价灭活分裂病毒流感疫苗(IIV4)。

随着老年人口的增长,对合适的流感疫苗的需求也在增加。为了控制老年人的季节性流感疫情,研究人员生产了一种由A和B系组成的四价灭活分裂病毒流感疫苗(IIV4)。在这项III期、随机、双盲、主动对照试验中,研究人员比较了IIV4与华兰生物工程公司在2019年流感季节生产的特许四价灭活疫苗(IIV4-HL)的安全性和免疫原性,研究结果已发表于Hum Vaccin Immunother。

将受试者随机分为IIV4组(n = 959)和IIV4-HL组(n = 959)。分析结果显示,与IIV4-HL相比,IIV4的血凝抑制(HAI)滴度的几何平均数(GMT)和血清转化率(SCR)在两个年龄组中都表现出更好的A系(H1N1和H3N2)抗体反应(P < 0.01)和B系(B/Yamagata和B/Victoria)同等抗体反应(P > 0.01)。免疫后,IIV4在老年人中提供了令人满意的SCR和血清保护率(SPR)。在两个年龄组之间没有观察到明显的免疫原性的变化。

 

在这两个年龄组中,IIV4和IIV4-HL受试者经历了类似水平的主动和非主动的不良事件(AEs),而且两组疫苗的AEs发生率都很低。大多数AEs为轻度至中度,IIV4组没有3级AEs,但在IIV4和IIV4-HL组中,60-65岁年龄组的AEs略高于≥65岁年龄组(IIV4:14.66% vs. 10.36%;IIV4-HL:14.67% vs. 11.43%)。

总的来说,该研究结果表明,在60岁及以上的成年人中,IIV4普遍耐受性良好,并能诱导老年人对所有四种流感病毒的高抗体滴度,因此,IIV4可作为候选疫苗用于60岁或以上的老年人预防季节性流感。

原始出处:

Renfeng Fan, et al.,  Safety and immunogenicity of a quadrivalent influenza vaccine in adults aged 60 years or above: a phase III randomized controlled clinical study. Hum Vaccin Immunother. 2022 Dec 31;18(1):1-9. doi: 10.1080/21645515.2021.1967041.  

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    2023-03-21 kalseyzl
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