JAMA Pediatr:美国儿童及青少年新冠肺炎流行病学研究

2020-11-24 MedSci原创 MedSci原创

在这项针对美国儿科患者的大型队列研究中,儿童的SARS-CoV-2感染率较低,临床表现一般较轻。黑人、西班牙裔和亚洲人群;青春期和成年早期;非呼吸性慢性疾病人群的感染风险较高

目前美国是严重急性呼吸综合征冠状病毒2(SARS-CoV-2)流行的重灾区,近日研究人员就美国儿童及青少年SARS-CoV-2的检测和感染流行病学情况进行了考察。
 
研究人员对135794名25岁以下患者数据进行回顾性队列研究,数据来自PEDSnet数据库,由美国7个儿科健康网络系统组成,包含11个州的650万名病患。参与研究的患者在2020年1月1日至9月8日期间接受 新冠肺炎病毒检测。数据分析于2020年9月8日至24日进行。研究的主要终点为SARS-CoV-2感染与2019年冠状病毒病(COVID-19)。
 
共有135794名儿童患者,53%为男性,平均年龄8.8岁,亚洲裔占3%,黑人占15%,西班牙裔占11%,白人占59%,每10000人口中290人进行了SARS-CoV-2检测,5374(4%)人阳性,每10000人中有12人感染新冠肺炎病毒。与白人相比,黑人、西班牙裔和亚洲族裔人群的检测率较低(比值比分别为0.70、0.65和0.60),但检测结果呈阳性的可能性更大(风险比分别为2.66、3.75和2.04)。年龄较大(5-11岁OR=1.25;12-17岁OR=1.92;18-24岁OR=3.51)、医疗保险(1.43)、门诊检查(2.13)和急诊科检查(3.16)人群的感染风险较高。单变量分析中,非恶性慢性病人群的检测可能性较低,而先前存在的呼吸系统疾病人群的检测阳性风险较低(标准化比率[SR]0.78),然而,其他几个诊断组的阳性风险较高,包括恶性疾病(SR=1.54),心脏疾病(1.18),内分泌疾病(1.52),胃肠道疾病(2.00),遗传疾病(1.19)、血液系统疾病(1.26)、肌肉骨骼疾病(1.18)、精神健康障碍(1.20)和代谢紊乱(1.42)。在5374例阳性的患者中,359例(7%)因呼吸性、低血压或COVID-19特异性疾病住院治疗,其中,99例(28%)需要重症监护,33例(9%)需要机械通气。病死率为0.2%(8/5374)。与2018年或2019年相比,2020年初诊断为川崎病的患者数量减少了40%(259 vs 433和430 )。
 
在这项针对美国儿科患者的大型队列研究中,儿童的SARS-CoV-2感染率较低,临床表现一般较轻。黑人、西班牙裔和亚洲人群;青春期和成年早期;非呼吸性慢性疾病人群的感染风险较高。
 
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    2021-01-20 feather89
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    2020-11-26 xugumin
  4. [GetPortalCommentsPageByObjectIdResponse(id=1728724, encodeId=5b1d1e2872480, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 20 21:10:14 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639661, encodeId=c3601639661eb, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Mar 23 16:10:14 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1411374, encodeId=62a914113e428, content=<a href='/topic/show?id=91e96538eee' target=_blank style='color:#2F92EE;'>#流行病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65387, encryptionId=91e96538eee, topicName=流行病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Thu Nov 26 12:10:14 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902049, encodeId=b55e90204929, content=<a href='/topic/show?id=7f8a104050b5' target=_blank style='color:#2F92EE;'>#美国近120万儿童感染新冠#</a> 据CNN报道,美国儿科学会发布的最新数据显示,11月5日至19日,美国报告新增儿童感染新冠肺炎病例144145例,比之前两周增加28%;美国已有近120万儿童感染,<a href='/topic/show?id=52ab104051da' target=_blank style='color:#2F92EE;'>#儿童病例在美国新冠病例中占比超11%#</a>。此外,美国多地住院病例数还在持续激增,加州过去两周住院病例激增77%。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104050, encryptionId=7f8a104050b5, topicName=美国近120万儿童感染新冠), TopicDto(id=104051, encryptionId=52ab104051da, topicName=儿童病例在美国新冠病例中占比超11%)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Wed Nov 25 08:52:44 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028810, encodeId=b83610288104e, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed Nov 25 00:10:14 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036353, encodeId=7b091036353f7, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Nov 25 00:10:14 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901944, encodeId=b28190194438, content=这种文章对于有娃的需要多关注了,希望疫情早点走了😁, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Tue Nov 24 21:19:25 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-11-25 BJying

    #美国近120万儿童感染新冠# 据CNN报道,美国儿科学会发布的最新数据显示,11月5日至19日,美国报告新增儿童感染新冠肺炎病例144145例,比之前两周增加28%;美国已有近120万儿童感染,#儿童病例在美国新冠病例中占比超11%#。此外,美国多地住院病例数还在持续激增,加州过去两周住院病例激增77%。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1728724, encodeId=5b1d1e2872480, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 20 21:10:14 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639661, encodeId=c3601639661eb, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Mar 23 16:10:14 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1411374, encodeId=62a914113e428, content=<a href='/topic/show?id=91e96538eee' target=_blank style='color:#2F92EE;'>#流行病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65387, encryptionId=91e96538eee, topicName=流行病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Thu Nov 26 12:10:14 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902049, encodeId=b55e90204929, content=<a href='/topic/show?id=7f8a104050b5' target=_blank style='color:#2F92EE;'>#美国近120万儿童感染新冠#</a> 据CNN报道,美国儿科学会发布的最新数据显示,11月5日至19日,美国报告新增儿童感染新冠肺炎病例144145例,比之前两周增加28%;美国已有近120万儿童感染,<a href='/topic/show?id=52ab104051da' target=_blank style='color:#2F92EE;'>#儿童病例在美国新冠病例中占比超11%#</a>。此外,美国多地住院病例数还在持续激增,加州过去两周住院病例激增77%。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104050, encryptionId=7f8a104050b5, topicName=美国近120万儿童感染新冠), TopicDto(id=104051, encryptionId=52ab104051da, topicName=儿童病例在美国新冠病例中占比超11%)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Wed Nov 25 08:52:44 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028810, encodeId=b83610288104e, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed Nov 25 00:10:14 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036353, encodeId=7b091036353f7, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Nov 25 00:10:14 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901944, encodeId=b28190194438, content=这种文章对于有娃的需要多关注了,希望疫情早点走了😁, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Tue Nov 24 21:19:25 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-11-25 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1728724, encodeId=5b1d1e2872480, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 20 21:10:14 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639661, encodeId=c3601639661eb, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Mar 23 16:10:14 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1411374, encodeId=62a914113e428, content=<a href='/topic/show?id=91e96538eee' target=_blank style='color:#2F92EE;'>#流行病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65387, encryptionId=91e96538eee, topicName=流行病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Thu Nov 26 12:10:14 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902049, encodeId=b55e90204929, content=<a href='/topic/show?id=7f8a104050b5' target=_blank style='color:#2F92EE;'>#美国近120万儿童感染新冠#</a> 据CNN报道,美国儿科学会发布的最新数据显示,11月5日至19日,美国报告新增儿童感染新冠肺炎病例144145例,比之前两周增加28%;美国已有近120万儿童感染,<a href='/topic/show?id=52ab104051da' target=_blank style='color:#2F92EE;'>#儿童病例在美国新冠病例中占比超11%#</a>。此外,美国多地住院病例数还在持续激增,加州过去两周住院病例激增77%。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104050, encryptionId=7f8a104050b5, topicName=美国近120万儿童感染新冠), TopicDto(id=104051, encryptionId=52ab104051da, topicName=儿童病例在美国新冠病例中占比超11%)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Wed Nov 25 08:52:44 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028810, encodeId=b83610288104e, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed Nov 25 00:10:14 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036353, encodeId=7b091036353f7, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Nov 25 00:10:14 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901944, encodeId=b28190194438, content=这种文章对于有娃的需要多关注了,希望疫情早点走了😁, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Tue Nov 24 21:19:25 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-11-25 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1728724, encodeId=5b1d1e2872480, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 20 21:10:14 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639661, encodeId=c3601639661eb, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Mar 23 16:10:14 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1411374, encodeId=62a914113e428, content=<a href='/topic/show?id=91e96538eee' target=_blank style='color:#2F92EE;'>#流行病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65387, encryptionId=91e96538eee, topicName=流行病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Thu Nov 26 12:10:14 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902049, encodeId=b55e90204929, content=<a href='/topic/show?id=7f8a104050b5' target=_blank style='color:#2F92EE;'>#美国近120万儿童感染新冠#</a> 据CNN报道,美国儿科学会发布的最新数据显示,11月5日至19日,美国报告新增儿童感染新冠肺炎病例144145例,比之前两周增加28%;美国已有近120万儿童感染,<a href='/topic/show?id=52ab104051da' target=_blank style='color:#2F92EE;'>#儿童病例在美国新冠病例中占比超11%#</a>。此外,美国多地住院病例数还在持续激增,加州过去两周住院病例激增77%。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104050, encryptionId=7f8a104050b5, topicName=美国近120万儿童感染新冠), TopicDto(id=104051, encryptionId=52ab104051da, topicName=儿童病例在美国新冠病例中占比超11%)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Wed Nov 25 08:52:44 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028810, encodeId=b83610288104e, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed Nov 25 00:10:14 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036353, encodeId=7b091036353f7, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Nov 25 00:10:14 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901944, encodeId=b28190194438, content=这种文章对于有娃的需要多关注了,希望疫情早点走了😁, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Tue Nov 24 21:19:25 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-11-24 水-晶

    这种文章对于有娃的需要多关注了,希望疫情早点走了😁

    0

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