Stroke:急性缺血性卒中后的吸烟状况和功能结局

2020-01-03 xing.T MedSci原创

由此可见,当前和最近吸烟与急性缺血性卒中后3个月出现不良的功能结局风险增加有关。

吸烟是卒中已知的危险因素。然而,尚不确定卒中前吸烟状态是否会影响急性缺血性卒中的临床结局。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,这项研究旨在阐明急性缺血性卒中后吸烟状况与功能结局之间的关系。

研究人员使用日本一家基于多中心医院的卒中登记系统,对2007年7月至2017年12月期间住院的10825例急性缺血性卒中患者进行了调查,这些患者在卒中发作之前具有功能独立性。吸烟状况可分为从未吸烟者(不吸烟者)、既往吸烟者和当前吸烟者。临床结局包括3个月时不良功能结局(改良的Rankin量表评分≥2)和功能依赖性(改良的Rankin量表评分2-5)。研究人员使用Logistic回归分析对潜在的混杂因素进行了调整。

患者的平均年龄为70.2±12.2岁,女性为37.0%。有4396名(42.7%)非吸烟者,3328名(32.4%)既往吸烟者和2561名(24.9%)当前吸烟者。在调整混杂因素后,功能不良的比值比(95%CI)在当前吸烟者中有所增加(与不吸烟者相比为1.29 [1.11-1.49]),而在既往吸烟者中则没有(与不吸烟者相比为1.05[0.92-1.21])。然而,在既往吸烟者中,卒中发作后两年内戒烟的受试者不良功能结局的几率较高(与不吸烟者相比为1.75 [1.15-2.66])。随着当前吸烟者日吸烟量的增加,不良功能结局的风险倾向于增加(趋势P=0.002)。维持所有这些关联是为了功能依赖性。

由此可见,当前和最近吸烟与急性缺血性卒中后3个月出现不良的功能结局风险增加有关。

原始出处:

Ryu Matsuo.et al.Smoking Status and Functional Outcomes After Acute Ischemic Stroke.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.027230

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    2020-01-04 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2020-01-03 qingfengqishi5

    学习了,学习了

    0

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