J Periodontol:肝病药物熊去氧胆酸可抑制牙周细胞促炎细胞因子的表达

2020-08-23 MedSci原创 MedSci原创

牙周病是一种常见的口腔慢性炎症疾病,包括牙周炎,坏死性牙周炎和作为系统性疾病表现的牙周炎。多种全身性疾病与牙周病的进展和严重程度有关。流行病学证据表明,肝脏受损患者发生牙周病的风险较高。

牙周病是一种常见的口腔慢性炎症疾病,包括牙周炎,坏死性牙周炎和作为系统性疾病表现的牙周炎。多种全身性疾病与牙周病的进展和严重程度有关。流行病学证据表明,肝脏受损患者发生牙周病的风险较高。部分肝硬化的危险因素包括酗酒、超重或肥胖、乙型或丙型病毒性肝炎等,与牙周病的发生有关。

熊去氧胆酸(UDCA)是治疗胆汁性肝病的一种一线治疗药物,UDCA是否具有牙周抗炎作用受到了我们关注。

将牙龈成纤维细胞和口腔人类鳞癌细胞系HSC-2暴露于白细胞介素(IL)1β和肿瘤坏死因子(TNF)α,培养体系中以加/不加UDCA作为分组。将小鼠RAW 264.7巨噬细胞与含有UDCA的无菌人唾液孵育。逆转录聚合酶链反应检测炎性细胞因子的表达。免疫分析法检测IL6的产生。将p65亚基进行免疫染色,以进一步分析UDCA的抗炎作用。

结果发现,UDCA显著降低了IL1β和TNFα诱导的IL1、IL6和IL8在牙龈成纤维细胞和HSC-2细胞系中的表达。在RAW 264.7巨噬细胞中,UDCA抑制了唾液中IL1α、IL1β和IL6表达的增加。免疫检测发现,UDCA能够减少炎症诱导的牙龈成纤维细胞、HSC-2和RAW 264.7细胞中IL6的产生。免疫染色显示,UDCA阻断了牙龈成纤维细胞中p65的核转移。

因此,UDCA可在体外抑制口腔成纤维细胞、口腔人鳞癌细胞和巨噬细胞中炎症细胞因子的表达。胆汁淤积性肝病患者服用UDCA可能有益于牙周健康。

原文出处:

Reza Talebian,Ursodeoxycholic acid attenuates the expression of proinflammatory cytokines in periodontal cells,Journal of Periodontology,2020,8.

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topicList=[TopicDto(id=39588, encryptionId=e35439588ea, topicName=周细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17fd36043248, createdName=mhm301, createdTime=Mon Feb 22 09:18:32 CST 2021, time=2021-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809628, encodeId=acf118096285c, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Sat Sep 19 12:18:32 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283662, encodeId=e7dd12836626a, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1363765, encodeId=a91e1363e65fd, content=<a href='/topic/show?id=00556e3243e' target=_blank style='color:#2F92EE;'>#熊去氧胆酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67324, encryptionId=00556e3243e, topicName=熊去氧胆酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451319, encodeId=11fb14513194d, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812646, encodeId=61858126464b, content=UDCA可在体外抑制口腔成纤维细胞、口腔人鳞癌细胞和巨噬细胞中炎症细胞因子的表达。胆汁淤积性肝病患者服用UDCA可能有益于牙周健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Mon Aug 24 10:16:33 CST 2020, time=2020-08-24, status=1, ipAttribution=)]
    2021-02-22 mhm301
  5. [GetPortalCommentsPageByObjectIdResponse(id=1728642, encodeId=c2731e286427d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Dec 07 10:18:32 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690065, encodeId=9b2a1690065e8, content=<a href='/topic/show?id=fb802e08724' target=_blank style='color:#2F92EE;'>#促炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27087, encryptionId=fb802e08724, topicName=促炎)], attachment=null, authenticateStatus=null, createdAvatar=null, 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href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1363765, encodeId=a91e1363e65fd, content=<a href='/topic/show?id=00556e3243e' target=_blank style='color:#2F92EE;'>#熊去氧胆酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67324, encryptionId=00556e3243e, topicName=熊去氧胆酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451319, encodeId=11fb14513194d, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812646, encodeId=61858126464b, content=UDCA可在体外抑制口腔成纤维细胞、口腔人鳞癌细胞和巨噬细胞中炎症细胞因子的表达。胆汁淤积性肝病患者服用UDCA可能有益于牙周健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Mon Aug 24 10:16:33 CST 2020, time=2020-08-24, status=1, ipAttribution=)]
  6. 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href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1363765, encodeId=a91e1363e65fd, content=<a href='/topic/show?id=00556e3243e' target=_blank style='color:#2F92EE;'>#熊去氧胆酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67324, encryptionId=00556e3243e, topicName=熊去氧胆酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451319, encodeId=11fb14513194d, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812646, encodeId=61858126464b, content=UDCA可在体外抑制口腔成纤维细胞、口腔人鳞癌细胞和巨噬细胞中炎症细胞因子的表达。胆汁淤积性肝病患者服用UDCA可能有益于牙周健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Mon Aug 24 10:16:33 CST 2020, time=2020-08-24, status=1, ipAttribution=)]
  7. 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href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1363765, encodeId=a91e1363e65fd, content=<a href='/topic/show?id=00556e3243e' target=_blank style='color:#2F92EE;'>#熊去氧胆酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67324, encryptionId=00556e3243e, topicName=熊去氧胆酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451319, encodeId=11fb14513194d, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812646, encodeId=61858126464b, content=UDCA可在体外抑制口腔成纤维细胞、口腔人鳞癌细胞和巨噬细胞中炎症细胞因子的表达。胆汁淤积性肝病患者服用UDCA可能有益于牙周健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Mon Aug 24 10:16:33 CST 2020, time=2020-08-24, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1728642, encodeId=c2731e286427d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Dec 07 10:18:32 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690065, encodeId=9b2a1690065e8, content=<a href='/topic/show?id=fb802e08724' target=_blank style='color:#2F92EE;'>#促炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27087, encryptionId=fb802e08724, topicName=促炎)], attachment=null, authenticateStatus=null, createdAvatar=null, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451319, encodeId=11fb14513194d, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Aug 25 13:18:32 CST 2020, time=2020-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812646, encodeId=61858126464b, content=UDCA可在体外抑制口腔成纤维细胞、口腔人鳞癌细胞和巨噬细胞中炎症细胞因子的表达。胆汁淤积性肝病患者服用UDCA可能有益于牙周健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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  9. 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createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Mon Aug 24 10:16:33 CST 2020, time=2020-08-24, status=1, ipAttribution=)]
    2020-08-24 神盾医疗局局长Jack

    UDCA可在体外抑制口腔成纤维细胞、口腔人鳞癌细胞和巨噬细胞中炎症细胞因子的表达。胆汁淤积性肝病患者服用UDCA可能有益于牙周健康

    0

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