Rheumatology:银屑病和银屑病关节炎是否与孕妇的不良妊娠结局有关?

2021-10-31 MedSci原创 MedSci原创

银屑病和PsA是影响育龄期妇女的炎症性疾病。近日,发表于Rheumatology (Oxford)的一项荟萃分析调查了母亲的银屑病和PsA是否与不良妊娠结局有关。

银屑病和PsA是影响育龄期妇女的炎症性疾病。近日,发表于Rheumatology (Oxford)的一项荟萃分析调查了母亲的银屑病和PsA是否与不良妊娠结局有关。

研究人员搜索了2020年8月3日之前多个电子数据库收录的相关文章。纳入报告患有银屑病或PsA的妇女至少有一次妊娠结局,并有一般人群或健康受试者作为比较对象的观察性研究。通过随机效应模型汇集数据,并以几率(OR)和95%CI表示。

 

结果,这项荟萃分析共纳入16项研究。汇总分析显示,与普通人群相比,患有银屑病的孕妇发生不良妊娠结局的风险明显较高[剖腹产:1.33(1.17,1.52);早产:1.32(1.15,1.52);(先兆)子痫:1.28(1.14,1.43);妊娠期糖尿病:1.19(1.10,1.30);妊娠期高血压:1.30(1.18,1.44)] 。然而,在患有银屑病的妇女中没有观察到胎儿并发症风险的明显增加[胎龄小:1.02(0.93,1.11);出生体重低:1.15(0.93,1.42);先天性畸形:1.03(0.93,1.14);Apgar评分<7:1.07(0.81,1.39);新生儿死亡率:1.13(0.90,1.43);死胎:1.19(0.95,1.50)] 。亚组分析发现,无论是银屑病还是PsA的妇女在孕产结果方面都有类似的结果,虽然PsA的风险估计值更大,但并没有统计学差异。

综上所述,该研究结果表明,患有银屑病和PsA的孕妇分娩不良事件的风险较高,但新生儿不良事件的发生风险并不高。在日常工作中,需要对母亲在怀孕前和怀孕期间的临床状况进行密切监测。

 

原始出处:

 

Wenhui Xie, et al., Maternal and neonatal outcomes in pregnant women with psoriasis and psoriatic arthritis: a systematic review and meta-analysis. Rheumatology (Oxford). 2021 Sep 1;60(9):4018-4028. doi: 10.1093/rheumatology/keab357.

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