Lancet infect dis:漱口水可预防男男性活动传播口咽淋病?

2021-03-07 Nebula MedSci原创

漱口水可预防男男性活动传播口咽淋病?

在过去10年中,很多国家的淋病发生率急剧增加。此外,淋病奈瑟菌的抗菌素耐药性也已成为公共卫生的一个迫切威胁。为了解决淋病和抗菌素耐药发生率的增加,本研究旨在对比Listerine和Biotène两种漱口水在预防与男性发生性关系(MSM)的男性感染淋病的效果。

OMEGA试验是一项多中心、平行组、双盲的随机对照试验,招募16-24岁的在20天内经核酸扩增试验(NAAT)诊断为口咽淋病的男性,随机分至两组,接受Listerine(实验组)或Biotène(对照组)漱口,每天至少一次,每次20ml,每次60秒,持续用12周。主要终点是在12周期间任何时间点被诊断为口咽N球菌感染的MSM比例。

2016年3月30日-2018年10月26日,共筛查了786位MSM,排除了其中256位,Biotène组和Listerine组分别有264位和266位MSM;最终分别有227位(86%)和219位(82%)被纳入分析。

两组口咽淋病发生率

Biotène组227位MSM中有10位(4%)检出口咽淋病,而Listerine组219位MSM中有15位(7%)检出了口咽淋病(校正风险差 2.5%,95% CI -1.8~6.8)。两组随访至12周时口咽淋病的累积发生率无明显差异(校正风险差 3.1%,95% CI -1.4~7.7)。

检出淋病奈瑟菌的男性比例和调整风险差异

总之,与Biotène漱口水相比,Listerine漱口水并不能降低口咽淋病的发生率。然而,既往研究提示,漱口水或可降低口咽淋病的感染率;因此,进一步研究漱口水对淋病奈瑟菌的抑制作用是有必要的,以确定它是否有具有预防淋病传播的潜在作用。

原始出处:

Eric P F Chow, et al. Antiseptic mouthwash for gonorrhoea prevention (OMEGA): a randomised, double-blind, parallel-group, multicentre trial. The Lancet Infectious Disease. March 04, 2021.

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    2021-08-04 howi
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    2022-01-20 zhaojie88
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    2021-05-02 fyxzlh
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    2021-03-08 科研科研科研

    男男性病漱口水

    0

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    2021-03-08 神盾医疗局局长Jack

    没有作用

    0

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    2021-03-08 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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    2021-03-07 言西早

    淋病奈瑟菌的抗菌素耐药性也已成为公共卫生的一个迫切威胁。

    0

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