Brit J Cancer:炎症标志物对癌症诊断的价值

2019-04-24 xing.T 网络

由此可见,在炎症标志物升高的患者中应考虑癌症。然而,炎症标志物对癌症的敏感性较差,因此不能用作“排除”检查。

在初级保健中早期识别癌症非常重要且具有挑战性。近日,肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章,该研究的目的是评估初级保健中检测炎症标志物(C-反应蛋白、红细胞沉降率和血浆粘度)对癌症诊断的效用。

研究人员使用临床实践研究数据链(CPRD)与癌症登记处进行关联,对2014年160000名检测过炎症标志物的参与者和40000名未经检测的匹配对照者进行队列研究。该研究的主要结局是一年的癌症发病率。

炎症标志物升高的初级保健患者一年癌症发病率为3.53%(95%CI为3.37-3.70),而炎症标志物正常者为1.50%(1.43-1.58),未经检测的对照者为0.97%(0.87-1.07)。炎症标志物水平越高,年龄越大,男性越高,癌症风险越大;当重复检测异常时风险进一步上升,但如果重复检测正常则下降。50岁以上的男性和60岁以上的女性炎症标志物升高,其癌症风险超过紧急调查的3%NICE阈值。CRP的敏感性为46.1%,ESR为43.6%,PV为49.7%。 

由此可见,在炎症标志物升高的患者中应考虑癌症。然而,炎症标志物对癌症的敏感性较差,因此不能用作“排除”检查。 

原始出处:

Jessica Watson,et al.Predictive value of inflammatory markers for cancer diagnosis in primary care: a prospective cohort study using electronic health records.British Journal of Cancer. 2019.https://www.nature.com/articles/s41416-019-0458-x

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