Behavioural Brain Research: 人类纹状体和眶额皮质中视觉性刺激的主观奖励价值编码

2020-07-22 MedSci原创 MedSci原创

人类神经影像学研究表明,纹状体和眶额皮质中存在一种用于奖励的主观评估的核心网络。

视觉性刺激(VSS)的主观奖励值的神经表示以及这些主观评估在相关成瘾行为发展中的作用的研究很少。作者使用功能磁共振成像(fMRI)研究了对VSS的神经反应性如何与个人偏好相关联。

方法:在fMRI扫描期间,有72名男子查看了不同的VSS胶片剪辑。收集有性唤起的等级,并在功能磁共振成像分析中用作参数调节器。受试者还填写了有关有问题的色情使用(PPU)的自我报告症状的问卷。首先,我们发现在所有受试者中,伏隔核,尾状核和眶额皮层中对VSS夹的神经反应性与各自VSS的个体评分呈正相关。第二,神经活动与性唤起等级之间的关联强度与PPU的自我报告症状呈正相关。

结果:第一个结果表明,在已建立的奖励评估区域中,可以根据个人偏好对VSS进行精确评估。其次,基于具有更多PPU症状的参与者的偏爱,更强的神经分化表明个人偏好匹配在这些个体中的重要性越来越高。个体喜好与神经活动之间这种高度对应关系可能会通过增加激励显着性信号来促进PPU的发展,从而增强寻找和响应这些优选刺激的方法。

原文链接:

Klein, S., et al., Subjective reward value of visual sexual stimuli is coded in human striatum and orbitofrontal cortex. Behavioural Brain Research, 2020. 393: p. 112792.https://doi.org/10.1016/j.bbr.2020.112792

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    2020-07-24 zywlvao
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    2020-07-24 qjddjq
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    2020-07-24 yangshch
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