Clinica Chimica Acta：术前淋巴细胞与单核细胞比值对上尿路上皮癌的预测价值

2019-08-08 不详 MedSci原创

本研究的目的是探讨术前淋巴细胞单核细胞比<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:"Calibri","sans-serif"; mso-fareast-font-family:宋体;mso-bidi-font-family:"

本研究的目的是探讨术前淋巴细胞单核细胞比(LMR)对肾盂输尿管根治性切除术(RNU)后上尿路上皮癌(UTUC)病理及生存结局的预测价值。

本回顾性研究纳入2008年至2017年704例UTUC患者。采用Kaplan-Meier方法和logistic回归模型，用3.6的截止LMR来评估RNU术后肿瘤预后与RNU的关系。

研究发现，在平均随访39 月期间，术前LMR降低是不良病理结果的独立预测因子。Kaplan-Meier分析显示LMR低（<3.6）的患者具有较差的癌症特异性存活率（CSS），无复发生存期（RFS）和总体存活率（OS）; 对于具有高病理分级和更晚期UTUC的患者可确定该预后值，但对于具有低病理特征的患者则不确定。多变量Cox比例风险模型显示低LMR是CSS，RFS和OS较差的独立预测因子[风险比（HR）= 1.42，P = 0.02; HR = 1.39，P = 0.008; HR = 1.38，P = 0.017。

研究表明，术前LMR较低是RNU术后UTUC病理和肿瘤预后差的独立预测因子。亚组分析证实，LMR的预后价值仅限于高病理分级、晚期肿瘤患者。

原始出处：

TaoLi,HangXu,Predictive value of preoperative lymphocyte-to-monocyte ratio for patients with upper tract urothelial carcinoma

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2019-08-22 1508842480_96220437

#上尿路上皮癌#

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2020-05-19 windight

#CTA#

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2019-08-10 雕雕

#单核细胞#

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2019-08-10 wetgdt

#淋巴细胞#

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2019-08-10 mashirong

#上皮癌#

25 0
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2019-08-10 changjitao2016

#预测价值#

27 0

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Clinica Chimica Acta：术前淋巴细胞与单核细胞比值对上尿路上皮癌的预测价值

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