Clin oral invest:新型根管封闭剂诱导小鼠皮下组织细胞的细胞毒性和细胞凋亡

2017-12-17 MedSci MedSci原创

本研究的目的是评估两种新型根管封闭剂:RealSeal XT1和Sealapex Xpress在小鼠皮下结缔组织中的体外细胞毒性和体内生物相容性。

本研究的目的是评估两种新型根管封闭剂:RealSeal XT1和Sealapex Xpress在小鼠皮下结缔组织中的体外细胞毒性和体内生物相容性。

材料和方法:使用MTT测定(one-way ANOVA),台盼蓝测试(Mann-Whitney)评价细胞活力和通过流式细胞仪测定细胞凋亡进而评估细胞毒性。将装有密封剂的聚乙烯管植入70只BALB / c小鼠皮下:6个实验组(n = 10 /组)和2个空白对照组(n = 5 /组)。在实验结束时(7,21和63天),取组织并进行组织学处理。除了反应性肉芽肿组织的厚度测量和嗜中性粒细胞计数(Kruskal-Wallis和Dunn's post test; Mann-Whitney)(α= 0.05)(μm)外,还评估了成血管细胞增殖和水肿(Fisher精确检验)。

结果:MTT法,台盼蓝染色法和凋亡细胞分析显示呈剂量依赖性:封闭剂越稀释,细胞毒性越小。关于成血管细胞增殖和水肿,密封剂在第7和第63天之间有差异(p <0.05)。两种根管封闭剂最初促进周围组织反应形成异物肉芽肿,引发组织反应。

结论:两种密封剂都呈现剂量依赖性并促进了有效的皮下组织反应;密封剂Sealapex Xpress比RealSeal XT细胞毒性更低,生物相容性更好。

原始出处:

L. A. B. Silva, et al. Novel endodontic sealers induce cell cytotoxicity and apoptosis in a dose-dependent behavior and favorable response in mice subcutaneous tissue. Clinical oral investigstions. 2017 December. doi:10.1007/s00784-017-2087-1

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    2017-12-22 小几洁
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createdName=1e1850b7m51(暂无匿称), createdTime=Mon Feb 26 14:20:41 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290850, encodeId=deb0290850fe, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sun Feb 25 18:25:36 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
  4. 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encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Nov 07 07:42:00 CST 2018, time=2018-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061232, encodeId=ee102061232ce, content=<a href='/topic/show?id=5bd4622567b' target=_blank style='color:#2F92EE;'>#根管封闭剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62256, encryptionId=5bd4622567b, topicName=根管封闭剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Tue Jun 19 12:42:00 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292580, encodeId=21ce29258046, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sat Mar 03 10:28:57 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292325, encodeId=a36429232524, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Fri Mar 02 17:09:25 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292105, encodeId=fc2529210529, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Thu Mar 01 22:03:37 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291720, encodeId=e84a291e20a5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Wed Feb 28 15:05:56 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291466, encodeId=354629146634, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Tue Feb 27 19:56:42 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291101, encodeId=b7f0291101f2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Mon Feb 26 14:20:41 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290850, encodeId=deb0290850fe, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sun Feb 25 18:25:36 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-03-03 1e1850b7m51(暂无匿称)

    学习

    0

  5. 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encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Nov 07 07:42:00 CST 2018, time=2018-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061232, encodeId=ee102061232ce, content=<a href='/topic/show?id=5bd4622567b' target=_blank style='color:#2F92EE;'>#根管封闭剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62256, encryptionId=5bd4622567b, topicName=根管封闭剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Tue Jun 19 12:42:00 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292580, encodeId=21ce29258046, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sat Mar 03 10:28:57 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292325, encodeId=a36429232524, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Fri Mar 02 17:09:25 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292105, encodeId=fc2529210529, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Thu Mar 01 22:03:37 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291720, encodeId=e84a291e20a5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Wed Feb 28 15:05:56 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291466, encodeId=354629146634, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Tue Feb 27 19:56:42 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291101, encodeId=b7f0291101f2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Mon Feb 26 14:20:41 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290850, encodeId=deb0290850fe, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sun Feb 25 18:25:36 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-03-02 1e1850b7m51(暂无匿称)

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2020321, encodeId=7a0a2020321a5, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Fri Dec 22 10:42:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051003, encodeId=d3b42051003a0, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Nov 07 07:42:00 CST 2018, time=2018-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061232, encodeId=ee102061232ce, content=<a href='/topic/show?id=5bd4622567b' target=_blank style='color:#2F92EE;'>#根管封闭剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62256, encryptionId=5bd4622567b, topicName=根管封闭剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Tue Jun 19 12:42:00 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292580, encodeId=21ce29258046, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sat Mar 03 10:28:57 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292325, encodeId=a36429232524, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Fri Mar 02 17:09:25 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292105, encodeId=fc2529210529, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Thu Mar 01 22:03:37 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291720, encodeId=e84a291e20a5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Wed Feb 28 15:05:56 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291466, encodeId=354629146634, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Tue Feb 27 19:56:42 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291101, encodeId=b7f0291101f2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Mon Feb 26 14:20:41 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290850, encodeId=deb0290850fe, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sun Feb 25 18:25:36 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-03-01 1e1850b7m51(暂无匿称)

    学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2020321, encodeId=7a0a2020321a5, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Fri Dec 22 10:42:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051003, encodeId=d3b42051003a0, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Nov 07 07:42:00 CST 2018, time=2018-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061232, encodeId=ee102061232ce, content=<a href='/topic/show?id=5bd4622567b' target=_blank style='color:#2F92EE;'>#根管封闭剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62256, encryptionId=5bd4622567b, topicName=根管封闭剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Tue Jun 19 12:42:00 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292580, encodeId=21ce29258046, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sat Mar 03 10:28:57 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292325, encodeId=a36429232524, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Fri Mar 02 17:09:25 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292105, encodeId=fc2529210529, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Thu Mar 01 22:03:37 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291720, encodeId=e84a291e20a5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Wed Feb 28 15:05:56 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291466, encodeId=354629146634, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Tue Feb 27 19:56:42 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291101, encodeId=b7f0291101f2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Mon Feb 26 14:20:41 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290850, encodeId=deb0290850fe, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sun Feb 25 18:25:36 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-02-28 1e1850b7m51(暂无匿称)

    学习

    0

  8. 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encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Nov 07 07:42:00 CST 2018, time=2018-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061232, encodeId=ee102061232ce, content=<a href='/topic/show?id=5bd4622567b' target=_blank style='color:#2F92EE;'>#根管封闭剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62256, encryptionId=5bd4622567b, topicName=根管封闭剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Tue Jun 19 12:42:00 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292580, encodeId=21ce29258046, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sat Mar 03 10:28:57 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292325, encodeId=a36429232524, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Fri Mar 02 17:09:25 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292105, encodeId=fc2529210529, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Thu Mar 01 22:03:37 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291720, encodeId=e84a291e20a5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Wed Feb 28 15:05:56 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291466, encodeId=354629146634, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Tue Feb 27 19:56:42 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291101, encodeId=b7f0291101f2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Mon Feb 26 14:20:41 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290850, encodeId=deb0290850fe, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sun Feb 25 18:25:36 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-02-27 1e1850b7m51(暂无匿称)

    学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2020321, encodeId=7a0a2020321a5, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Fri Dec 22 10:42:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051003, encodeId=d3b42051003a0, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Nov 07 07:42:00 CST 2018, time=2018-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061232, encodeId=ee102061232ce, content=<a href='/topic/show?id=5bd4622567b' target=_blank style='color:#2F92EE;'>#根管封闭剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62256, encryptionId=5bd4622567b, topicName=根管封闭剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Tue Jun 19 12:42:00 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292580, encodeId=21ce29258046, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sat Mar 03 10:28:57 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292325, encodeId=a36429232524, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Fri Mar 02 17:09:25 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292105, encodeId=fc2529210529, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Thu Mar 01 22:03:37 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291720, encodeId=e84a291e20a5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Wed Feb 28 15:05:56 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291466, encodeId=354629146634, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Tue Feb 27 19:56:42 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291101, encodeId=b7f0291101f2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Mon Feb 26 14:20:41 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290850, encodeId=deb0290850fe, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sun Feb 25 18:25:36 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-02-26 1e1850b7m51(暂无匿称)

    学习

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Sat Mar 03 10:28:57 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292325, encodeId=a36429232524, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Fri Mar 02 17:09:25 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292105, encodeId=fc2529210529, content=学习, beContent=null, 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    2018-02-25 1e1850b7m51(暂无匿称)

    学习

    0

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