BMC Endocr Disord：转移部位对神经内分泌肿瘤（NEN）患者生存的影响

2020-04-23 MedSci原创 MedSci原创

神经内分泌肿瘤（NENs）根据肿瘤的起源和级别表现出不同的行为。我们假设肿瘤起源和转移部位可能在生存中起到一定的作用。

神经内分泌肿瘤（NENs）根据肿瘤的起源和级别表现出不同的行为。我们假设肿瘤起源和转移部位可能在生存中起到一定的作用。

我们查询了SEER数据库（2010-2014年）中确诊为NENs并记录了转移部位的患者，确定了2005例患者。通过Kaplan-Meier方法估计各时间点的总体生存（OS），并使用Cox比例危害模型评估了相关变量与OS的关系。

结果显示，肺、肝、骨和脑转移患者中分别有9、77、7和6%的转移患者发生肺、肝、骨和脑转移。在多变量模型中，转移位置与较差的生存率显著相关（肝HR：1.677（1.226-2.294）；（骨转移HR：1.412（0.965-2.065）；脑HR：1.666（1.177-2.357））。我们根据原发部位、转移部位、转移位置、年龄、性别、组织学和肿瘤大小制作了一套评分系统，可以将转移性NEN患者分为低危、中危和高危三类，帮助医生进行决策。

综上所述，该研究结果表明，转移部位在转移性NEN患者的生存中起着重要作用，而与通常描述的预后因素无关，应在生存估计中予以考虑。

原始出处：

Nikolaos A. Trikalinos, et al., Effect of metastatic site on survival in patients with neuroendocrine neoplasms (NENs). An analysis of SEER data from 2010 to 2014. BMC Endocr Disord. 2020; 20: 44. doi: 10.1186/s12902-020-0525-6

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2020-10-13 lily1616

#神经内分泌#

29 0
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2020-05-09 一叶知秋

#分泌#

29 0
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2021-01-26 1249898am27暂无昵称

#内分泌肿瘤#

37 0
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2021-02-02 tastas

#患者生存#

34 0
[GetPortalCommentsPageByObjectIdResponse(id=1953767, encodeId=bae61953e67e1, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Tue Oct 13 18:28:23 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682603, encodeId=d32e168260380, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat May 09 10:28:23 CST 2020, time=2020-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763512, encodeId=fd651e6351269, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Tue Jan 26 15:28:23 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932675, encodeId=257719326e5aa, content=<a href='/topic/show?id=5cd95305803' target=_blank style='color:#2F92EE;'>#患者生存#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53058, encryptionId=5cd95305803, topicName=患者生存)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Tue Feb 02 23:28:23 CST 2021, time=2021-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784421, encodeId=e62c1e8442155, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Sat Jan 23 13:28:23 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013316, encodeId=d931201331616, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Feb 13 23:28:23 CST 2021, time=2021-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975017, encodeId=611d19e5017b0, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Tue Feb 09 04:28:23 CST 2021, time=2021-02-09, status=1, ipAttribution=)]
2021-01-23 cmsvly

#Disord#

17 0
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2021-02-13 cmj8wellington

#Dis#

25 0
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2021-02-09 ms3025846204744509

#BMC#

23 0

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