Cell:宝宝肠道菌群紊乱怎么办?母体粪便微生物群移植效果显著

2020-10-14 张佳兴 生物探索

新生儿的微生物定植是决定其健康成长的关键。基因组学分析和菌株水平分析表明,正常婴儿肠道中早期以产妇粪便细菌为主,其中主要包括双歧杆菌和拟杆菌。停止母乳喂养后,粪便微生物群逐渐变成厌氧梭状芽胞杆菌。

新生儿的微生物定植是决定其健康成长的关键。基因组学分析和菌株水平分析表明,正常婴儿肠道中早期以产妇粪便细菌为主,其中主要包括双歧杆菌和拟杆菌。停止母乳喂养后,粪便微生物群逐渐变成厌氧梭状芽胞杆菌。

这种现象在所有人群中都是普遍存在的,可能是人类正常发育过程中不可或缺的生物学现象。因此,人类系统很可能已经适应了特定时间窗口内的特定微生物信号,从而在生命的早期进行了相互的免疫和代谢调控。

2020年10月1日,《Cell 》杂志在线发表了芬兰赫尔辛基大学Willem M. de Vos 课题组的研究成果,该研究发现,剖宫产婴儿的母体粪便微生物菌群移植可迅速恢复正常肠道微生物发育。

该研究招募了17位母亲,经过筛选后采集了7位母亲分娩前3周粪便样本。研究人员评估了是否可以通过出生后口服粪便微生物菌群移植(FMT)恢复剖宫产(CS)婴儿受干扰的肠道菌群。7个新生儿(5个男孩,2个女孩)进行了FMT手术,除一名婴儿接受7 mg移植物外,所有婴儿均接受了3.5 mg移植物。在7个月的随访中,所有7例婴儿的临床过程均正常,未见不良反应。

FMT处理的CS分娩的婴儿特征

随后,研究人员发现,母亲粪便样品中的微生物群非常相似,但与FMT处理的婴儿样品中的微生物群有很大差异,表明移植后的高度选择性生长。母亲的微生物群主要由瘤胃菌科和毛螺旋菌科组成。胎粪样品主要为气单胞菌。七个婴儿中有六个婴儿表现出与拟杆菌和双歧杆菌属相同的微生物群发育。在2天的粪便样品中,微生物群几乎完全由拟杆菌属组成。到7天时,双歧杆菌已成为优势群体。在4周样本中,除肠杆菌科和拟杆菌属外,双歧杆菌也含量丰富。

母体和FMT处理过的婴儿样品中的家庭水平菌群组成

为了进一步详述移植治疗婴儿的微生物群发育,研究人员测试了阴道分娩的婴儿与CS FMT治疗和未治疗婴儿之间的微生物群差异。在出生后的头几天,接受FMT治疗的婴儿的微生物菌群与经阴道分娩的婴儿的菌群有所不同,但是从7天起,经FMT治疗的婴儿的菌群与经阴道分娩的婴儿的菌群多样性和时间发育相似,并且与未治疗的CS婴儿相比差异显着。

与未治疗CS和经阴道分娩的婴儿相比,FMT处理过的婴儿的平均相对菌群情况

模式图

许多慢性疾病与CS的出生有关,其中婴儿异常的微生物群是重要因素之一。但目前还没有安全有效的方法可以完全恢复CS婴儿的菌群。该研究发现,剖宫产婴儿的肠道菌群发育有别于与阴道分娩的婴儿,并且,可以通过母亲粪便微生物菌群移植来纠正这种偏离。但是,只有经过严格的临床和微生物筛选后才能进行此操作哦。

原始出处:

Katri Korpela, Otto Helve, Kaija-Leena Kolho,et al.Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study.Cell. 2020 Sep 18;S0092-8674(20)31089-8. doi: 10.1016/j.cell.2020.08.047.

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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892139, encodeId=8d4c892139c4, content=最近肠道菌群越来越火啦! 是一件好事,让人们越来越意识到肠道菌群的重要性!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Oct 14 23:10:21 CST 2020, time=2020-10-14, status=1, ipAttribution=)]
  8. 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  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892139, encodeId=8d4c892139c4, content=最近肠道菌群越来越火啦! 是一件好事,让人们越来越意识到肠道菌群的重要性!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Oct 14 23:10:21 CST 2020, time=2020-10-14, status=1, ipAttribution=)]
    2020-10-16 Homburg
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href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Fri Oct 16 06:31:27 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466939, encodeId=7ab61466939ad, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Fri Oct 16 06:31:27 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892139, encodeId=8d4c892139c4, content=最近肠道菌群越来越火啦! 是一件好事,让人们越来越意识到肠道菌群的重要性!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Oct 14 23:10:21 CST 2020, time=2020-10-14, status=1, ipAttribution=)]
    2020-10-14 Jessica

    最近肠道菌群越来越火啦! 是一件好事,让人们越来越意识到肠道菌群的重要性!

    0

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